Electroencephalographic and Clinical Effects of Total Corpus Callosotomy
Despite the availability of over 20 antiepileptic drugs (AEDs) and AED level monitoring, many patients continue to have seizures that are frequent and severe enough to cause physical injury. When the epileptic tissue can be demonstrated to be isolated to a surgically resectable part of the cortex lobectomy or topectomy can be performed, often with very gratifying results (Rasmussen, 1975). However, when the patient is found to have rapid secondary generalization from a surgically unapproachable lesion (because of size or location) or from multiple sites the surgical option has generally been excluded, even in cases of clear medical treatment failure
KeywordsNeurol Neuroblastoma Carbamazepine Hydrocephalus Encephalitis
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- Bogen, J. E., and Vogel, P. J., 1962, Cerebral commissurotomy in man, Bull. Los Angeles Neurol. Soc. 27: 169–172.Google Scholar
- Huck, F. R., Radvany, J., Avila, J. O., Pires de Camargo, C. H., Marino, R., Jr., Ragazzo, P. C., Riva, D., and Arlant, P., 1980, Anterior callosotomy in epileptics with multiform seizures and bilateral synchronous spike and wave EEG pattern, Acta Neurochir. Suppl. 30: 127–135.Google Scholar
- Rasmussen, T., 1975, Cortical resection in the treatment of focal epilepsy, in: Advances in Neurology, Vol, 8, Neurosurgical Management of the Epilepsies ( D. P. Purpura, J. K. Penry, and R. D. Walter, eds.), Raven Press, New York, pp. 139–154.Google Scholar
- Van Wagenen, W. P., and Herren, R. Y., 1940, Surgical division of commissural pathways in the corpus callosum. Relation to spread of an epileptic attack, Arch. Neurol. 44: 740–759.Google Scholar