Electroencephalographic and Clinical Effects of Total Corpus Callosotomy
Despite the availability of over 20 antiepileptic drugs (AEDs) and AED level monitoring, many patients continue to have seizures that are frequent and severe enough to cause physical injury. When the epileptic tissue can be demonstrated to be isolated to a surgically resectable part of the cortex lobectomy or topectomy can be performed, often with very gratifying results (Rasmussen, 1975). However, when the patient is found to have rapid secondary generalization from a surgically unapproachable lesion (because of size or location) or from multiple sites the surgical option has generally been excluded, even in cases of clear medical treatment failure
KeywordsCorpus Callosum Anterior Commissure Epileptiform Discharge Birth Trauma Intractable Seizure
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