Disorders of Bone Marrow
Disorders of the bone marrow are a rare occurrence in the practice of obstetrics and gynecology. However, once failure of the multipotential hematopoietic stem cell occurs, the resulting pancytopenia (anemia, neutropenia, and thromtocytopenia) is devastating. A hypocellular bone marrow with fatty degenerative changes is called aplastic anemia.1,2 On the other hand, the rare selective aplasia of the erythropoietic cell line is designated as pure red blood cell aplasia. When the bone marrow is replaced with either tumor or granulomatous changes, myelophthistic anemia is the diagnosis. Finally, paroxysmal nocturnal hemoglobinuria is thought to be caused by the bone marrow production of an abnormal clone of defective red cells, platelets, and granulocytes.
KeywordsAplastic Anemia Paroxysmal Nocturnal Hemoglobinuria Megaloblastic Anemia Antiplatelet Antibody Bone Marrow Production
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