Disorders of Bone Marrow

  • Sue M. Palmer
  • John C. Morrison


Disorders of the bone marrow are a rare occurrence in the practice of obstetrics and gynecology. However, once failure of the multipotential hematopoietic stem cell occurs, the resulting pancytopenia (anemia, neutropenia, and thromtocytopenia) is devastating. A hypocellular bone marrow with fatty degenerative changes is called aplastic anemia.1,2 On the other hand, the rare selective aplasia of the erythropoietic cell line is designated as pure red blood cell aplasia. When the bone marrow is replaced with either tumor or granulomatous changes, myelophthistic anemia is the diagnosis. Finally, paroxysmal nocturnal hemoglobinuria is thought to be caused by the bone marrow production of an abnormal clone of defective red cells, platelets, and granulocytes.


Aplastic Anemia Paroxysmal Nocturnal Hemoglobinuria Megaloblastic Anemia Antiplatelet Antibody Bone Marrow Production 
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  1. 1.
    Erslev AJ: Erythrocyte disorders—anemas related to disturbance of stem cell proliferation or differentiation, in Williams WJ, Beuttler E, Erslev AJ et al (eds): Hematology, ed 2. New York, McGraw-Hill, 1977, pp 258–299Google Scholar
  2. 2.
    Rappeport JM, Bunn HF: Bone marrow failure: Aplastic anemia and other disorders of the bone marrow, in Isselbacher KJ, Adams E, Braunwald E, et al (eds): Principles of Internal Medicine, ed 9. New York, McGraw-Hill, 1980, pp 1525–1530Google Scholar
  3. 3.
    Suda T, Omine M, Tsuchija J, et al: Prognostic aspects of aplastic anemia in pregnancy, Blut 36: 285–298, 1978PubMedCrossRefGoogle Scholar
  4. 4.
    Issaragrisil S, Vanachivanavin V, Piankijagum A, et al: A-plastic anemia with pregnancy. J Med Assoc Thailand 65: 111–114, 1982Google Scholar
  5. 5.
    Willoughby ML: Haematological disorders. Clin Obstet Gynecol 4: 371–394, 1977Google Scholar
  6. 6.
    Lehman G: Reversible pure red cell hypoplasia in pregnancy. JAMA 247: 1170–1171, 1982PubMedCrossRefGoogle Scholar
  7. 7.
    Hurd W, Meodovnik M, Step S: Pregnancy associated with paroxysmal nocturnal hemoglobinuria. Obstet Gynecol 60: 742–756, 1982PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • Sue M. Palmer
  • John C. Morrison

There are no affiliations available

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