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Multiple Sclerosis: An Abiotrophy with Heuristic Implications

  • Chapter
Multiple Sclerosis

Part of the book series: Ettore Majorana International Science Series ((PHYSC,volume 16))

Abstract

These words remain as cogent today as when penned; neither is it widely appreciated that 0.5–1.0% of all MS patients are first referred to a psychiatrist (personal communication from Dr. L.H. Field). The existence of totally “silent” cases of MS is now well established (Georgi, 1961; Vost et al., 1864; Ghatek et al., 1974; Morariu and Klutzow, 1976; Castaigne et al., 1981). Georgi’s series is biggest and best known. He found amongst 15,644 autopsies carried out at Basle Institute of Pathological Anatomy, 68 cases of anatomically demonstrable MS, in 12 of which (18%) the disease had not been at all suspected during life. Mackay and Hirano (1967) were of the considered option that “perhaps clinically silent multiple sclerosis occurs in about one case for each four definitely diagnosed clinically”.

“The normal process of acceptance of a scientific idea is in four stages,

(i) this is worthless nonsense

(ii) this is an interesting, but perverse point of view

(iii) this is true but quite unimportant

(iv) I have always said so.”

J.B.S. Haldane, 1963, J.Genetics, 58:464

“Unless the lay public are taught to appreciate the potential significance of such symptoms as the temporary weakness in a limb, transient dimness of vision, and diplopia the latter part of Buzzard’s (1897) criticism ‘the fullgrown disease is frequently not recognized, the infant disease practically never’ must remain justified.”

D.K. Adams et al., 1950, Brit.Med.J., ii:431

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  1. Crossley House Neurological Research Centre, 17 Brighton Grove, Newcastle upon Tyne, NE4 5NS, England

    E. J. Field

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  1. Neurological Department, Univeristy of Milan, Milan, Italy

    G. Scarlato

  2. University of Oxford, Oxford, UK

    W. B. Matthews

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Field, E.J. (1984). Multiple Sclerosis: An Abiotrophy with Heuristic Implications. In: Scarlato, G., Matthews, W.B. (eds) Multiple Sclerosis. Ettore Majorana International Science Series, vol 16. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2403-4_9

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