Multiple Sclerosis: An Abiotrophy with Heuristic Implications

  • E. J. Field
Part of the Ettore Majorana International Science Series book series (EMISS, volume 16)

Abstract

These words remain as cogent today as when penned; neither is it widely appreciated that 0.5–1.0% of all MS patients are first referred to a psychiatrist (personal communication from Dr. L.H. Field). The existence of totally “silent” cases of MS is now well established (Georgi, 1961; Vost et al., 1864; Ghatek et al., 1974; Morariu and Klutzow, 1976; Castaigne et al., 1981). Georgi’s series is biggest and best known. He found amongst 15,644 autopsies carried out at Basle Institute of Pathological Anatomy, 68 cases of anatomically demonstrable MS, in 12 of which (18%) the disease had not been at all suspected during life. Mackay and Hirano (1967) were of the considered option that “perhaps clinically silent multiple sclerosis occurs in about one case for each four definitely diagnosed clinically”.

Keywords

Permeability Migraine Influenza Osteoarthritis Prostaglandin 

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • E. J. Field
    • 1
  1. 1.Crossley House Neurological Research CentreNewcastle upon TyneEngland

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