Skip to main content
SpringerLink
Log in

Clinical Implications of Studies Involving Cerebrospinal Fluid T Cell Subpopulations

  • Chapter
Multiple Sclerosis

Part of the book series: Ettore Majorana International Science Series ((PHYSC,volume 16))

  • 80 Accesses

Abstract

Multiple sclerosis (MS) is a demyelinating central nervous system (CNS) affliction manifested by exacerbations and remissions of clinical symptoms.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 16.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. R. P. Lisak, A. I. Levinson, B. Zweiman, and N. I. Abdou, T and B lymphocytes in multiple sclerosis, Clin.Exp.Immunol., 22: 30 (1975).

    Google Scholar 

  2. H. J. Sagar and I. D. Allonby, Lymphocyte subpopulations in multiple sclerosis, J.neurol Sci., 43: 133 (1979).

    Article  Google Scholar 

  3. J. R. Huddlestone and M. B. A. Oldstone, T suppressor (TQ) lymphocytes fluctuate in parallel with changes in the clinical course of patients with multiple sclerosis, J.Immunol 123: 1615 (1979).

    Google Scholar 

  4. E. L. Reinherz, H. L. Weiner, S. L. Hauser, J. A. Cohen, J. A. Distaso, and S. F. Schlossman, Loss of suppressor T cells in active multiple sclerosis, N.Engl.J.Med., 303: 125 (1980).

    Article  Google Scholar 

  5. M.-A. Bach, F. Phan-Dinh-Tuy, E. Tournier, L. Chatenoud, J.-F. Bach, C. Martin, and J.-D. Degos, Deficit of suppressor T cells in active multiple sclerosis, Lancet 2: 1221 (1980).

    Article  Google Scholar 

  6. J. Sandberg-Wollheim, Lymphocyte populations in the cerebrospinal fluid and peripheral blood of patients with multiple sclerosis and optic neuritis, Scan.J.Immunol. 17: 575 (1983).

    Article  Google Scholar 

  7. J. F. Oger, B. G. W. Arnason, S. H. Wray, and J. P. Kistler, A study of B and T cells in multiple sclerosis, Neurology 25: 444 (1975).

    Article  Google Scholar 

  8. S. L. Hauser, H. L. Weiner, and K. A. Ault, Clonally restricted B cells in peripheral blood of multiple sclerosis patients: Kappa/Lambda staining patterns, Ann.Neurol 11: 408 (1981).

    Article  Google Scholar 

  9. J. C. Allen, W. Sheremata, J. B. R. Cosgrove, K. Osterland, and M. Shea, Cerebrospinal fluid T and B lymphocyte kinetics related to exacerbations of multiple sclerosis, Neurology 26: 579 (1976).

    Article  Google Scholar 

  10. P. K. Coyle, B. R. Brooks, R. L. Hirsch, S. R. Cohen, P. O’Donnell, R. T. Johnson, and J. S. Wolinsky, Cerebrospinal-Fluid lymphocyte populations and immune complexes in active multiple sclerosis, Lancet 2: 229 (1980).

    Article  Google Scholar 

  11. H. S. Panitch and G. S. Francis, T-lymphocyte subsets in cerebrospinal fluid in multiple sclerosis, N.Eng.J.Med., 397: 560 (1982).

    Google Scholar 

  12. J. Oger, J. P. Antel, A. Noronha, and B. G. W. Arnason, Changes in T-cell subpopulations in the cerebrospinal fluid of multiple sclerosis patients, Neurology 32: A148 (1982).

    Google Scholar 

  13. N. Cashman, C. Martin, J.-F Eizenbaum, J.-D. Degos and M.-A. Bach, Monoclonal antibody-defined immunoregulatory cells in multiple sclerosis cerebrospinal fluid, J.Clin.Invest., 70: 387 (1982).

    Article  Google Scholar 

  14. H. Weiner, S. L. Hauser, S. F. Schlossman, and E. L. Reinherz, Analysis of CSF mononuclear cells in multiple sclerosis using monoclonal antibodies: Correlation with disease activity and peripheral blood T-cell subset changes, Neurology 33: A165 (1982).

    Google Scholar 

  15. S. L. Hauser, E. L. Reinherz, C. J. Hoban, S. F. Schlossman and H. L. Weiner, CSF cells in multiple sclerosis, Monoclonal antibody analysis and relationship to peripheral blood T-cell subsets, Neurology 33: 575 (1983).

    Article  Google Scholar 

  16. S. L. Hauser, E. L. Reinherz, C. J. Hoban, S. F. Schlossman and H. L. Weiner, Immunoregulatory T-cells and lymphocytotoxic antibodies in active multiple sclerosis: Weekly analysis over a six-month period, Ann Neurol., 13: 418 (1983).

    Article  Google Scholar 

  17. J. R. Huddlestone and M. B. A. Oldstone, Suppressor T cells are activated in vivo in patients with multiple sclerosis coinciding with remission from attack, J.Immunol., 129: 915 (1982).

    Google Scholar 

  18. O. J. Kolar, P. H. Rice, F. H. Jones, R. J. DeFalque, and J. Kincaid, Cerebrospinal fluid immunoelectrophoresis in multiple sclerosis, J.Neurol Sci., 47: 221 (1980).

    Article  Google Scholar 

  19. H. Nyland, R. Matre, S. Mørk, J.-R. Bjerke, and A. Naess, T-lymphocyte subpopulations in multiple-sclerosis lesions, N.Engl.J.Med., 307: 1643 (1982).

    Google Scholar 

  20. C. J. J. Brinkman, H. H. ter Laak, O. R. Hommes, S. Poppema, and P. Delmotte, T-lymphocyte subpopulations in multiple sclerosis lesions, N.Engl.J.Med., 307: 1644 (1982).

    Google Scholar 

  21. G. W Hunninghake and R. G. Crystal, A disorder mediated by excess helper T-lymphocyte activity at sites of disease activity, N.Engl.J.Med., 305: 429 (1981).

    Article  Google Scholar 

  22. W. C. Van Voorhis, G. Kaplan, E. N. Sarno, M. A. Horwitz, R. M. Steinman, W. R. Levis, N. Nogueira, L. S. Hair, C. R. Gattass, B. A. Arrick, and Z. A. Cohn, The cutaneous infiltrates of leprosy: Cellular characteristics and the predominant T-cell phenotypes, N.Engl.J.Med., 307: 1593 (1982).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Neurology, Microbiology and Immunology, and Anesthesiology, Multiple Sclerosis Research Laboratory, USA

    O. J. Kolar, P. H. Rice, D. C. Bauer, R. J. Defalque, C. F. Danielson, M. R. Farlow & J. H. Wright

  2. Indiana University School of Medicine and the Department of Computing Services, Indiana University-Purdue, University at Indianapolis, 46223, USA

    O. J. Kolar, P. H. Rice, D. C. Bauer, R. J. Defalque, C. F. Danielson, M. R. Farlow & J. H. Wright

Authors
  1. O. J. Kolar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. H. Rice
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. C. Bauer
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. J. Defalque
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. C. F. Danielson
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. M. R. Farlow
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. J. H. Wright
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Neurological Department, Univeristy of Milan, Milan, Italy

    G. Scarlato

  2. University of Oxford, Oxford, UK

    W. B. Matthews

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Plenum Press, New York

About this chapter

Cite this chapter

Kolar, O.J. et al. (1984). Clinical Implications of Studies Involving Cerebrospinal Fluid T Cell Subpopulations. In: Scarlato, G., Matthews, W.B. (eds) Multiple Sclerosis. Ettore Majorana International Science Series, vol 16. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2403-4_14

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2403-4_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9465-8

  • Online ISBN: 978-1-4613-2403-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation