Abstract
Aphidicolin, an inhibitor of DNA polymerase oc, was shown to induce a very high frequency of endoreduplication in Chinese hamster V79 cells. The aphidicolin-induced endoreduplication was inhibited when cells were incubated at 41° C. Since it is known that DNA polymerase β is more thermally labile than DNA polymerase oc, the data are consistent with the hypothesis that DNA polymerase β might be responsible for endoreduplication.
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© 1984 Plenum Press, New York
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Huang, Y.Q., Chang, C.C., Trosko, J.E. (1984). Aphidicolin Induces Endoreduplication in Chinese Hamster Cells. In: Chu, E.H.Y., Generoso, W.M. (eds) Mutation, Cancer, and Malformation. Environmental Science Research, vol 31. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2399-0_56
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DOI: https://doi.org/10.1007/978-1-4613-2399-0_56
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9463-4
Online ISBN: 978-1-4613-2399-0
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