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Aphidicolin Induces Endoreduplication in Chinese Hamster Cells

  • Y. Q. Huang
  • C. C. Chang
  • James E. Trosko
Part of the Environmental Science Research book series (ESRH, volume 31)

Abstract

Aphidicolin, an inhibitor of DNA polymerase oc, was shown to induce a very high frequency of endoreduplication in Chinese hamster V79 cells. The aphidicolin-induced endoreduplication was inhibited when cells were incubated at 41° C. Since it is known that DNA polymerase β is more thermally labile than DNA polymerase oc, the data are consistent with the hypothesis that DNA polymerase β might be responsible for endoreduplication.

Keywords

Health Hazard Resolution Mass Active Fraction Oxidative Enzyme Organic Extract 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Y. Q. Huang
    • 1
  • C. C. Chang
    • 2
  • James E. Trosko
    • 2
  1. 1.Department of BiologyNanjing Teacher’s CollegeNanjingChina
  2. 2.Department of Pediatrics and Human Development, College of Human MedicineMichigan State UniversityEast LansingUSA

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