Advertisement

Induction of Sister Chromatid Exchanges with Gossypol Acetate in Mouse Spermatogonial Cells InVivo

  • R. L. Wang
  • M. M. Wang
  • Q. Lu
  • H. Z. Zhing
  • Y. L. Yao
  • X. R. Jiang
  • Z. S. Zhang
Part of the Environmental Science Research book series (ESRH, volume 31)

Abstract

This paper presents the results of testing gossypol acetate for the possible induction of sister chromatid exchanges (SCEs) in mouse spermatogonial cells in vivo following a single intraperitoneal injection of BudR adsorbed on charcoal. Our purpose was to elucidate the mutagenecity of gossypol. Animals were randomly divided into five groups: the lower, medium, and higher dosage groups (5, 20, and 50 times as high as gossypol clinical dosage, respectively), the negative control group and the positive control group (Mitomycin C 0.5 mg/kg b.w. ). The results are:
  1. 1.

    Comparing the SCE frequencies of the lower dosage group (1.42 ± 0.006/cell) and the medium dosage group (1.43 ± 0.06/cell) with the negative control group (1.43 ± 0.07/cell), the differences were not statiscally significant (p > 0.05).

     
  2. 2.

    The difference between the higher dosage group (1.84 ± 0.07/cell) and the negative control group was highly significant (p < 0.001).

     

Keywords

Dosage Group Negative Control Group High Dosage Group Sister Chromatid Exchange Research 3Shanghai Institute 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • R. L. Wang
    • 1
  • M. M. Wang
    • 2
  • Q. Lu
    • 3
  • H. Z. Zhing
    • 1
  • Y. L. Yao
    • 2
  • X. R. Jiang
    • 1
  • Z. S. Zhang
    • 1
  1. 1.Shanghai Institute of Planned Parenthood ResearchFudan UniversityShanghaiChina
  2. 2.Shanghai Institute of Pharmaceutical IndustryFudan UniversityShanghaiChina
  3. 3.Institute of GeneticsFudan UniversityShanghaiChina

Personalised recommendations