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Mutagenicity of Pesticides

  • Yasuhiko Shirasu
  • Masaaki Moriya
  • Hideo Tezuka
  • Shoji Teramoto
  • Toshihiro Ohta
  • Tatsuo Inoue
Part of the Environmental Science Research book series (ESRH, volume 31)

Summary

Microbial mutagenicity screening studies employing Ames tests were done on 228 pesticides. As a result, 50 compounds showed mutagenicity and five of them required metabolic activation for their activities. Among the various compound groups, organic phosphates, halogenated alkanes and dithiocarbamates contained mutagens at a higher ratio. Mutagenicity of these pesticides was less potent than that of other mutagens. Cytogenetic studies on the pesticides which were positive in microbial assays revealed a good correlation between the ability to induce sister chromatid exchanges or chromosomal aberrations and the mutagenic potency in bacteria. Dominant lethal studies on 1, 2-dibromo-3-chloropropane (DBCP) and ethylene dibromide (EDB) disclosed that DBCP gave positive results in rats but not in mice, although EDB was negative in both species. DBCP was also positive in a sex-linked recessive lethal test using Drosophila melanogaster. Occupational exposure to pesticides, especially gaseous ones like DBCP, in industry or in agriculture seems hazardous from the genetic toxicological point of view.

Keywords

Sodium Nitrite Maleic Hydrazide Heptachlor Epoxide Sodium Polyacrylate Piperonyl Butoxide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Yasuhiko Shirasu
  • Masaaki Moriya
    • 1
  • Hideo Tezuka
    • 1
  • Shoji Teramoto
    • 1
  • Toshihiro Ohta
    • 1
  • Tatsuo Inoue
    • 1
  1. 1.Institute of Environmental ToxicologyTokyoJapan

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