Summary
It is well recognized that carcinogenesis is affected to a great extent by the diet and nutritional status of the host, but the mechanisms involved, especially those related to undernutrition, are not clearly understood. In this report, the effects of overall undernutrition and specific nutrient deficiencies on carcinogenesis are reviewed. Specific examples concerning deficiencies of ascorbate, riboflavin, retinol, zinc, and protein are presented to demonstrate that these deficiencies may modify carcinogenesis by affecting carcinogen formation, carcinogen metabolism, tumor promotion, and other events. The possible effects of a cyclic or seasonal nutritional deficiency, which. may be common in rural areas, on carcinogenesis are discussed. Special attention is paid to the possible modification of the cytochrome P-450 mediated monooxygenase system and carcinogen activation by dietary and nutritional factors. The effects of alcohol and butylated hydroxyanisole on the metabolism of nitrosamines and benzo(a)pyrene are discussed to illustrate the mechanisms by which these dietary factors can affect carcinogenesis. The esophageal cancer problem in China is discussed to relate our current understanding of carcinogenesis to possible approaches of cancer prevention.
This work was supported by Grants CA-16788 and CA-28298 from the U.S. National Cancer Institute. Part of the travel expenses to China was provided by Miles Laboratories, Inc.
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Abbreviations
- BP:
-
benzo(a)pyrene
- P-450:
-
cytochrome P-450
- NDMA:
-
N-nitrosodimethylamine
- BHA:
-
butylated hydroxyanisole
- BP-9,10-diol:
-
9,10-dihydroxy-9,10-dihydroBP.
References
Anderson, M. W. , M. Boroujerdi, and A. G. E. Wilson (1981) Inhibition in vivo of the formation of adducts between metabolites of benzo(a)pyrene and DNA by butylated hydroxyanisole. Cancer Res. 41: 4309 – 4315.
Archer, M. D. , S. R. Tannenbaum, T. Y. Fan, and M. Weisman (1975) Reaction of nitrite with ascorbate and its relation to nitrosamine formation. J. Natl. Cancer Inst. 54: 1203 – 1205.
Benedict, W. F. , W. L. Wheatly, and P. A. Jones (1980) Inhibition of chemically induced morphological transformation and reversion of the transformed phenotype by ascorbic acid in C3H/10T 1/2 cells. Cancer Res. 40: 2796 – 2801.
Benson, A. M. , Y. N. Cha, E. Bueding, H. S. Heine, and P. Talalay (1979) Elevation of extrahepatic glutathione-S-transferase and epoxide hydrase activities of 2(3)-tert–butyl-4-hydroxyanisole. Cancer Res. 39: 2971 – 2977.
Benson, A. M. , R. P. Batzinger, S. Y. L. Ou, E. Bueding, Y. N. Cha, and P. Talalay (1978) Elevation of hepatic glutathione-S-transferase activities and protection against mutagenic metabolites of benzo(a)pyrene by dietary antioxidants. Cancer Res. 38: 4486 – 4495.
Bjelke, E. (1975) Dietary vitamin A and human lung cancer. Int. J. Cancer 15: 561 – 565.
Branen, A. L. (1975) Toxicology and biochemistry of butylated hydroxyanisole and butylated hydroxytoluene. J. Am. Oil Chem. Soc. 52: 59 – 63.
Campbell, T. C. (1982) Nutritional modulation of carcinogenesis, In Molecular Interactions of Nutrition and Cancer, M. S. Arnott, J. van Eys, and Y. –M. Wang, Eds. , Raven Press, New York, pp. 359 – 367.
Chaf Y. N. , F. Martz, and E. Bueding (1978) Enhancement of liver microsomal epoxide hydrase in rodents by treatment with 2(3)-tert-butyl-4-hydroxyanisole. Cancer Res. 38: 4496 – 4498.
Chan, P. C. , T. Okamoto, and E. L. Wynder (1972) Possible role of riboflavin deficiency in epithelial neoplasia. III. Induction of microsomal aryl hydrocarbon hydroxylase. J. Natl. Cancer Inst. 48: 1341 – 1345.
Clayson, D. B. (1975) Nutrition and experimental carcinogenesis: A review. Cancer Res. 35: 3292 – 3300.
Conney, A. H. (1982) Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons. Cancer Res. 42: 4875 – 4917.
Doll, R. , and R. Peto (1981) The causes of cancer. J. Natl. Cancer Inst. 66: 1191 – 1308.
Farber, E. (1981) Chemical carcinogenesis. New Engl. J. Med. 305: 1379 – 1389.
Fong, L. Y. Y. , and P. M. Newberne (1978) Zinc deficiency and methylbenzylnitrosamines-induced esophageal cancer in rats. J. Natl. Cancer Inst. 61: 145 – 150.
von Gibel, W. (1967) Experimentalle Untersuchungen zur Synkarzinogenese beim Osophagus-Karzinom. Arch. Geschwulstforsch 30: 181 – 189.
Good, R. A. , G. Fernandes, and N. K. Day (1982) The influence of nutrition on development of cancer immunity and resistance to mesenchymal diseases. In Molecular Interaction of Nutrition and Cancer, M. S. Arnott, J. van Eys, and Y. M. Wang, Eds. Raven Press, New York, pp. 73 – 89.
Graham, S. H. , M. Dayai, M. Swanson, A. Mittelman, and G. Wilkinson (1978) Diet in the epidemiology of cancer of the colon and rectum. J. Natl. Cancer Inst. 61: 709 – 714.
Griciute, L. , M. Castegnara, and J. C. Bereziat (1981) Influence of ethyl alcohol on carcinogenesis with N-nitrosodimethylamine. Cancer Lett. 13: 345 – 352.
Griffin, A. C. (1979) Role of selenium in the chemoprevention of cancer. Adv. Cancer Res. 29: 419 – 441.
Habs, H. , and D. Schmahl (1981) Inhibition of hepatocarcinogenic activity of diethylnitrosamine by ethanol in rats. Hepato-gastroenterol. 28: 242 – 244.
Haenszel, W. , P. Correa, C. Cuello, N. Guzman, L. Burbano, H. Lores, and J. Munoz (1976) Gastric cancer in Columbia: Case control epidemiological study of precursor lesions. J. Natl. Cancer Inst. 57: 1021 – 1026.
Haenszel, W. , M. Kuribara, M. Segi, and R. K. C. Lee (1972) Stomach cancer among Japanese in Hawaii. J. Natl. Cancer Inst. 49: 969 – 988.
Herter, F. P. , S. G. Weissman, and H. G. Thompson (1961) Clinical experience with 6-aminonicotinamide. Cancer Res. 21: 31 – 37.
Hirayama, T. (1979) Diet and cancer. Nutr. Cancer 1(3):67–81. 26. Ip, C. (1982) Dietary vitamin E intake and mammary carcinogenesis in rats. Carcinogenesis 3:1453–1456. 23. Kansler, C. J. , K. Sugiuraf N. F. Youngf C. R. Halter, and C. P. Rhoads (1941) Partial protection of rats by riboflavin with casein against liver cancer caused by dimethylaminoazobenzine. Science 93: 308 – 310.
Kappas, A. , K. E. Anderson, A. H. Oonn, and A. P. Alvares (1976) Influence of dietary protein and carbohydrate on antipyrine and theophylline metabolism in man. Chim. Pharmacol. Ther. 20: 643 – 653.
Kark, J. D. , A. H. Smith, B. R. Switzer, and C. G. Hames (1981) Serum vitamin A (retinol) and cancer incidence in Evans County, Georgia. J. Natl. Cancer Inst. 66: 7 – 16.
Lai, D. Y. , and J. S. Arcos (1980) Dialkylnitrosamine bioactivation and carcinogenesis. Life Sci. 27: 2149 – 2165.
Lam, L. K. T. , and L. W. Wattenberg (1971) Effects of butylated hydroxyanisole on the metabolism of benzo (a)pyrene by mouse liver microsomes. CL Natl. Cancer Inst. 58: 413 – 417.
Li, M. , P. Li, and B. Li (1980) Recent progress in research on esophageal cancer in China. Adv. Cancer Res. 33: 173 – 249.
Lu, A. Y. H. , and S. B. West (1980) Multiplicity of mammalian microsomal cytochromes P-450. Pharmacol. Rev. 31: 277 – 295.
MacLennan, R. , J. DaCosta, N. E. Day, C. H. Law, Y. K. Ng, and K. Shanmugaratnam (1977) Risk factors for lung cancer in Singapore Chinese, a population with high female incidence rates. Int. Cancer 20: 854 – 860.
Maling, H. M. , B. Stripp, J. G. Sipes, B. Highman, W. Saul, and M. A. Williams (1975) Enhanced hepatoxicity of carbon tetrachloride, thioacetamide, and dimethylnitrosamine by treatment of rat with ethanol and some comparisons with potentiation fcy isopropanol. Toxicol. Appl. Pharmacol. 33: 291 – 308.
Mergens, W. J. (1982) Efficacy of vitamin E to prevent nitrosamine formation. Ann. N. Y. Acad. Sci. 393: 61 – 69.
Mettlin, C. , S. Graham, and M. Sanson (1979) Vitamin A and lung cancer. Natl. Cancer Inst. 62: 1435 – 1438.
Mettlin, C. , and S. Graham (1979) Dietary risk factors in human bladder cancer. Am. J. Epidemiol. 110: 255 – 263.
Mihich, E. , and C. A. Nichol (1959) The effect of pyridoxine deficiency on mouse sarcoma 180. Cancer Res. 19: 279 – 284.
Miller, E. C. (1978) Some current perspectives on chemical carcinogenesis in humans and experimental animals. Cancer Res. 38: 1479 – 1496.
Mirvish, S. S. , L. Wallcave, M. Eagen, and P. Shubik (1972) Ascorbate-nitrite reaction: possible means of blocking the formation of carcinogenic N-nitroso compounds. Science 177: 65 – 68.
Morris, H. P. (1947) Effects on the genesis and grcwth of tumors associated with vitamin intake. Ann. N. Y. Acad. Sci. 49: 119 – 140.
Mueller, G. C. , and J. A. Miller (1950) The reductive cleavage of 4-dimethylaminoazobenzene by rat liver: Reactivation of carbon monoxide–treated homogenates fcy flavin adenine dinucleotide. J. Biol. Chem. 185: 145 – 154.
Nettesheim, P. (1979) Inhibition of carcinogenesis by retinoids. Canadian Med. Assoc. J. 122: 757 – 765.
Pantuck, E. J. , C. B. Pantuck, W. A. Garland, B. Mins, L. W. Wattenberg, K. E. Anderson, A. Kappas, and A. H. Connly (1979) Effects of dietary Brussels sprouts and cabbage on human drug metabolism. Clin. Pharmacol. Ther. 25: 88 – 95.
Peng, R. , P. Tennant, N. A. Lorr, and C. S. Yang (1983) Alteration of microsomal monooxygenase system and carcinogen metabolism by streptozotocin–induced diabetes in rats. Carcinogenesis 4: 703 – 708.
Peng, R. , Y. Y. Tu, and C. S. Yang (1982) The induction and competitive inhibition of a high affinity microsomal nitrosodimethylamine demethylase by ethanol. Carcinogenesis 3: 1457 – 1461.
Peto, R. , R. Doll, J. D. Buckly, and M. B. Sporn (1981) Can dietary B-carotene materially reduce human cancer rates? Nature 2%: 201 – 208.
Reddy, B. S. , L. A. Cohen, G. D. McCoy, P. Hill, J. H. Weisburger, and E. L. Wynder (1980) Nutrition and its relationship to cancer. Adv. Cancer Res. 32: 237 – 345.
Reddy, B. S. , L. Cohen, Y. Maeura, K. Fryura, and J. H. Weisburger (1983) Effect of dietary butylated hydroxytoluene or butylated hydroxyanisole on chemically induced intestinal and breast tumors in rats and mice. Fed. Proc. 42: abstract 5993.
Rivlin, R. S. (1973) Riboflavin and cancer: A review. Cancer Res. 33: 1977 – 1986.
Ross, M. H. , and G. Bras (1965) Tumor incidence patterns and nutrition in the rat. J. Nutrition 87: 245 – 260.
Sarkar, N. H. , G. Fernandes, N. T. Telang, I. A. Kourides, and R. A. Good (1982) Low-caloric diet prevents the development of mammary tumors in C3H mice and reduce circulating prolactin level, murine mammary tumor virus expression, and proliferation of mammary alveolar cells. Proc. Natl. Acad. Sci. USA 79: 7758 – 7762.
Schroder, E. W. , and P. H. Black (1980) Retinoids: Tumor preventers or tumor enhancers ? J. Natl. Cancer Inst. 65: 671 – 674.
Schwarz, M. , K. E. Appel, D. Schrenk, and W. Kunz (1980) Effect of ethanol on microsomal metabolism of dimethylnitrosamine. Cancer Res. Clin. Oncol. 97: 233 – 240.
Shklar, G. (1982) Oral mucosal carcinogenesis in hamsters: Inhibition by vitamin E. Natl. Cancer Inst. 68: 791 – 797.
Slaga, T. J. , A. J. P. Klein-Szanto, L. L. Triplett, and L. P. Yotti (1981) Skin tumor-promoting activity of benzoyl peroxide, a widely used free radical-generating compound. Science 213: 1023 – 1025.
Sporn, M. B. , and D. L. Newton (1979) Chemoprevention of cancer with retinoids. Fed. Proc. 38: 2528 – 2534.
Sydor, W. , M. W. Chou, S. K. Yang, and C. S. Yang (1983) Regioselective inhibition of benzyo (a)pyrene metabolism by butylated hydroxyanisol. Carcinogenesis 4:131–136. 59a. Sydor, W. , K. F. Lewis, and C. S. Yang (1984) Effects of butylated hydroxyanisole on the metabolism of benzo(a)pyrene by mouse lung microsomes. Cancer Res. 44: 134 – 138.
Swann, P. F. , D. G. Kaufman, P. N. Magee, and P. Mace (1980) Induction of kidney tumors by a single dose of dimethylnitrosamine: Dose response and influence of diet and benzo (a)pyrene pretreatment. Br. J. Cancer 41: 285 – 294.
Tannenbaum, A. (1940) The initiation and growth of tumors. I. Effects of underfeeding. Am. J. Cancer 38: 335 – 350.
Tannenbaum, A. (1942) The genesis and growth of tumors. II. Effects of caloric restriction per se. Cancer Res. 2: 460 – 467.
Tannenbaum, A. (1944) The dependence of the genesis of the induced skin tumors on the caloric intake during different stages of carcinogenesis. Cancer Res. 4: 673 – 677.
Troll, W. , G. Witz, B. Goldstein, D. Stone, and T. Sugimura(1982) The role of free oxygen radicals in tumor promotion and carcinogenesis, In Carcinogenesis Vol. 7, E. Hecker, N. E. Fusenig, W. Kung, F. Mark, and H. W. Thielmann, Eds. , Raven Press, New York, pp. 593 – 597.
Tu, Y. Y. , R. Peng, Z. F. Cheng, and C. S. Yang (1983) Induction of a high affinity nitrosamine demethylase in rat liver microsomes by acetone and isopropanol. Chem. Biol. Interactions 44: 247 – 260.
Tu, T. Y. , J. Sonnenberg, K. F. Lewis, and C. S. Yang (1981) Pyrazole-induced cytochrome P-450 in rat liver microsomes: An isozyme with high affinity for dimethylnitrosamine. Biochem. Biophys. Res. Cortmun. 103: 905 – 912.
Tu, Y. Y. , and C. S. Yang (1983) A high affinity nitrosamine dealkylase system in rat liver microsomes and its induction by fasting. Cancer Res. 43: 623 – 629.
Wattenberg, L. W. (1978) Inhibition of chemical carcinogenesis. Adv. Cancer Res. 26: 197 – 226.
Wattenberg, L. W. (1982) Inhibition of chemical carcinogenesis by minor dietary compounds, In Molecular Interactions of Nutrition and Cancer, M. S. Arnott, J. van Eys, and Y. M. Wang, Eds. , Raven Press, New York, pp. 43 – 56.
Weisburger, J. H. , E. L. Wynder, and C. L. Horn (1982) Nutritional factors and etiologic mechanisms in the causation of gastrointestinal cancers. Cancer 50: 2541 – 2549.
William, J. R. , P. H. Grantham, R. S. Yamamoto, and J. H. Weisburger (1970) Effect of dietary riboflavin on azo dye reductase in liver and in bacteria of cecal contents of rats. Biochem. Pharmacol. 19: 2523 – 2525.
Wynder, E. L. , and P. C. Chan (1970) The possible role of riboflavin deficiency in epithelial neoplasia. II. Effect on skin tumor development. Cancer 26: 1221 – 1224.
Winder, E. L. , and U. E. Klein (1965) The possible role of riboflavin deficiency in epithelial neoplasia. I. Epithelial changes of mice in simple deficiency. Cancer 18: 167 – 180.
Yang, C. S. (1974) Alterations of the aryl hydrocarbon hydroxylase system during riboflavin depletion and repletion. Arch. Biochem. Biophys. 160: 623 – 630.
Yang, C. S. (1980) Research on esophageal cancer in China: A review. Cancer Res. 40: 2633 – 2644.
Yang, C. S. , J. Miao, W. Yang, M. Huang, T. Wang, H. Xue, S. You, J. Lu, and J. Wu (1982) Diet and vitamin nutrition of the high esophageal cancer risk population in Linxian, China. Nutr. Cancer 4: 154 – 164.
Yang, C. S. , F. S. Strickhart, and G. K. Wu (1974) Inhibition of the monooxygenase system by butylated hydroxyanisole and butylated hydroxytoluene. Life Sci. 15: 1497 – 1505.
Yang, C. S. (1974) Alterations of the aryl hydrocarbon hydroxylase system during riboflavin depletion and repletion. Arch. Biochem. Biophys. 160: 623 – 630.
Yang, C. S. (1980) Research on esophageal cancer in China: A review. Cancer Res. 40: 2633 – 2644.
Yang, C. S. , W. Sydor, M. B. Martin, and K. F. Lewis (1981) Effects of butylated hydroxyanisole on the aryl hydrocarbon hydroxylase of rats and mice. Chem. Biol. Interactions 37: 337 – 350.
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© 1984 Plenum Press, New York
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Yang, C.S. (1984). Modification of Carcinogenesis by Dietary and Nutritional Factors. In: Chu, E.H.Y., Generoso, W.M. (eds) Mutation, Cancer, and Malformation. Environmental Science Research, vol 31. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2399-0_22
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