The Role of External Quality Assessment Schemes in the Determination of Plasma Drug Levels

  • John Williams
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 14)

Abstract

The advent and obvious advantages of therapeutic drug monitoring in the treatment of several disease states has resulted in a vast increase in the number of laboratory requests made for the measurement of plasma levels of drugs concerned. Although stringent internal quality control helps ensure the precision of the laboratory’s results, participation in external quality assessment schemes establishes the degree of accuracy of the assay procedure employed. This article describes a typical scheme and outlines benefits from the long-term feedback of information made available to scheme coordinators.

Keywords

HPLC Neurol Digoxin Theophylline Carbamazepine 

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References

  1. 1.
    Richens, A. (1975) in Clinical Pharmacology of Antiepileptic Drugs(Schneider, H., Janz, D., Gardner-Thorpe, C., Meinard, D. & Sherwin, A.L., eds.), Springer-Verlag, Heidelberg, pp. 293 – 303.Google Scholar
  2. 2.
    Pipppenger, C.E., Paris-Kutt, H., Penry, J.K. & Daley, D. (1976) Arch. Neurol.33, 351 – 355.Google Scholar
  3. 3.
    Healy, M.L.R. (1979) Clin. Chem. 25, 675 – 677.Google Scholar
  4. 4.
    Griffiths, A., Hebdige, E., Perucca, E. & Richens, A. (1980) Ther. Drug Monit. 2, 51 – 59.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • John Williams
    • 1
  1. 1.Department of Pharmacology and TherapeuticsWelsh National School of MedicineCardiffUK

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