Abstract
The discovery that mammalian brain possesses specific receptors for benzodiazepines has proved important not only for research studies but also clinically, due to the possibility of developing radioreceptor assays for their estimation in biological fluids. Such assays should, theoretically, have the advantage over purely chemical assays in that they reflect the total pharmacological ‘activity’ of both the parent compound and its active metabolites at the receptor. The approach hinges on competition between a radioactive ligand and the natural compound in the sample. It also depends, however, on the availability of membrane receptors in a suitable form.
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© 1984 Plenum Press, New York
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Ratnaraj, N., Goldberg, V., Lascelles, P.T. (1984). Receptor Binding and HPLC Analysis of Benzodiazepines in a Clinical Laboratory. In: Reid, E., Wilson, I.D. (eds) Drug Determination in Therapeutic and Forensic Contexts. Methodological Surveys in Biochemistry and Analysis, vol 14. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2397-6_39
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DOI: https://doi.org/10.1007/978-1-4613-2397-6_39
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