Abstract
Adriamycin, an anthracycline antibiotic with a broad spectrum of anti-tumour activity, is metabolized to at least 8 different products in man, all of which have been extracted from patient urine and identified using TLC [l]. These are adriamycinol (AOL), the major metabolite; 5 non-polar aglycones of adriamycin (ADR) and AOL, and two conjugated aglycones. The kinetics of several of the aglycones has been followed in 14 patients using TLC [2].
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© 1984 Plenum Press, New York
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Cummings, J., Stuart, J.F.B., McArdle, C.S., Calman, K.C. (1984). Identification of Adriamycin and its Metabolites in Human and Animal Tissue and Blood. In: Reid, E., Wilson, I.D. (eds) Drug Determination in Therapeutic and Forensic Contexts. Methodological Surveys in Biochemistry and Analysis, vol 14. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2397-6_31
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DOI: https://doi.org/10.1007/978-1-4613-2397-6_31
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