Abstract
The non-steroidal anti-oestrogen, tamoxifen [I], is currently used extensively in treatment of metastatic breast cancer and other disseminated oestrogen-dependent tumours, as well as in the ‘adjuvant’ context. It is extensively metabolized in man to two major biologically active products: the N-desmethyl [II] and 4-hydroxy [III] derivatives [1–3] (see overleaf). The former has estrogenic activity while the latter is strongly anti-oestrogenic [4]. The relative binding affinities of I, II and III for oestrogen receptors [4] and relative blood levels in patients [2, 4, 5] who had received the drug
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© 1984 Plenum Press, New York
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Sternson, L.A. (1984). HPLC Methodology for Therapeutic Monitoring of Tamoxifen and Two Major Metabolites in Blood and Tissues. In: Reid, E., Wilson, I.D. (eds) Drug Determination in Therapeutic and Forensic Contexts. Methodological Surveys in Biochemistry and Analysis, vol 14. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2397-6_28
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DOI: https://doi.org/10.1007/978-1-4613-2397-6_28
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