Analysis of Tamoxifen and its Metabolites

  • V. Craig Jordan
  • Richard R. Bain
  • Stewart D. Lyman
  • Raymond R. Brown
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 14)

Abstract

Tamoxifen is a non-steroidal anti-oestrogen used extensively in the treatment of breast cancer [l]. The usefulness of the drug and the interest in its mechanism of action have focused attention upon its pharmacokinetics and metabolism in animals and man (recently reviewed [2]). Several metabolites have been identified: metabolite B [3, 4], metabolite X [5] and metabolite Y [6,7]. Convenient assay systems are required for clinical monitoring of patients and for pharmacological studies.

Keywords

Tamoxifen NADPH Oestradiol Butanol Phenanthrene 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Mouridsen, H., Palshof, T., Patterson, J. & Battersby, L. (1978) Cancer Treat. Rev. 5, 1310 – 141.CrossRefGoogle Scholar
  2. 2.
    Jordan, V.C. (1982) Breast Cancer Res. Treat. 2, 123 – 138.CrossRefGoogle Scholar
  3. 3.
    Daniel, C.P., Gaskell, S.J., Bishop, H. & Nicholson, R.I. (1979) J. Endocrinol. 83, 401 – 408.CrossRefGoogle Scholar
  4. 4.
    Fabian, C., Tilzer, L. & Sternson, L. (1981) Biopharm. Drug Disp. 2, 381 – 390.CrossRefGoogle Scholar
  5. 5.
    Adam, H.K., Douglas, E.J. & Kemp, J.V. (1979) Biochem. Pharmacol. 27, 145 – 147.CrossRefGoogle Scholar
  6. 6.
    Bain, R.R. & Jordan, V.C. (1983) Biochem. Pharmacol. 32, 373 – 375.CrossRefGoogle Scholar
  7. 7.
    Jordan, V.C., Bain, R.R., Brown, R.R., Gosden, B. & Santos, M.S. (1983) Cancer Res. 43, 1446–1450.Google Scholar
  8. 8.
    Brown, R.R., Bain, R.R. & Jordan, V.C. (1983) J. Chromatog.272, 351 – 358.CrossRefGoogle Scholar
  9. 9.
    Golander, Y. & Sternson, L.A. (1980) J. Chromatog. 181, 41 – 49.CrossRefGoogle Scholar
  10. 10.
    Adam, H.K., Gay, M.A. & Moore, R.H. (1980) J. Endocrinol. 84, 35 – 42.CrossRefGoogle Scholar
  11. 11.
    Robertson, D.W., Katzenellenbogen, J.A., Long, D.J., Rorke, E.A. & Katzenellenbogen, B.S. (1982) J. Steroid Biochem. 16, 1 – 13.CrossRefGoogle Scholar
  12. 12.
    Borgna, J.-L. & Rochefort, H. (1981) J. Biol. Chem. 256, 859 – 868.Google Scholar
  13. 13.
    Jordan, V.C., Collins, M.D., Rowsby, L. & Prestwich, G. (1977) J. Endocrinol. 75, 305 – 316.CrossRefGoogle Scholar
  14. 14.
    Ruenitz, P.C. & Toledo, M.M. (1981) Biochem. Pharmacol. 30, 2203–2207.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • V. Craig Jordan
    • 1
  • Richard R. Bain
    • 1
  • Stewart D. Lyman
    • 1
  • Raymond R. Brown
    • 1
  1. 1.Department of Human Oncology Wisconsin Clinical Cancer CenterUniversity of WisconsinMadisonUSA

Personalised recommendations