Analysis of Tamoxifen and its Metabolites
Tamoxifen is a non-steroidal anti-oestrogen used extensively in the treatment of breast cancer [l]. The usefulness of the drug and the interest in its mechanism of action have focused attention upon its pharmacokinetics and metabolism in animals and man (recently reviewed ). Several metabolites have been identified: metabolite B [3, 4], metabolite X  and metabolite Y [6,7]. Convenient assay systems are required for clinical monitoring of patients and for pharmacological studies.
KeywordsCoating Solution Chicken Liver Serum Extract Tamoxifen Metabolite Isocratic Solvent System
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