Abstract
The therapeutic mode of action of gold is still unknown. Although the gold content of many biological materials has been determined by either atomic absorption spectrophotometry (AASJ or neutron activation analysis (NAA), no gold metabolites have as yet been identified. The monitoring of plasma gold levels during chrysotherapy correlates with the administered dose but not with either therapeutic efficacy or occurrence of toxic side- effects. In man after i.m. injection, plasma gold is mostly associated with albumin, while in the tissues of experimental animals the cytosolic subcellular fraction of the kidney has the highest levels of gold. The latter findings might relate to the detoxification and excretion of the metal.
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© 1984 Plenum Press, New York
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Ward, R.J. (1984). The Therapeutic Use of Gold Compounds: Analytical Aspects. In: Reid, E., Wilson, I.D. (eds) Drug Determination in Therapeutic and Forensic Contexts. Methodological Surveys in Biochemistry and Analysis, vol 14. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2397-6_18
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DOI: https://doi.org/10.1007/978-1-4613-2397-6_18
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