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Specific Element Chromatographic Detection by Plasma Spectral Emission, as Applied to Organometallics and Gold-Containing Drugs

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Drug Determination in Therapeutic and Forensic Contexts

Part of the book series: Methodological Surveys in Biochemistry and Analysis ((ANAY,volume 14))

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Abstract

Inorganic gas and liquid chromatographic analysis is finding application in bioanalytical areas. Characterization methods for complex samples include specific element detection. Plasma emission spectroscopy exhibits notable advantages for such detection by virtue of versatility, sensitivity, selectivity and multi-element capability. Among the plasma systems which have been evaluated, the atmospheric pressure microwave plasma has shown wide suitability for analysis of both metallic and non-metallic elements; high-resolution capillary GC maximizes detection limits. Thus, trialkyl Pb compounds have been determined, directly and as organometallic derivatives, in aqueous samples down to ppb after suitable extraction and pre-concentration procedures. Other published examples include characterization of fluorine-containing metabolites in blood plasma and determination of boronate esters and steroidal carboranes.

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Authors and Affiliations

  1. Department of Chemistry, GRC Towers, University of Massachusetts, Amherst, MA, 01003, USA

    Peter C. Uden

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  1. Peter C. Uden
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Editor information

Editors and Affiliations

  1. Guildford Academic Associates, Guildford, Surrey, UK

    Eric Reid

  2. Hoechst Pharmaceutical Research Laboratories, Milton Keynes, UK

    Ian D. Wilson

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© 1984 Plenum Press, New York

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Uden, P.C. (1984). Specific Element Chromatographic Detection by Plasma Spectral Emission, as Applied to Organometallics and Gold-Containing Drugs. In: Reid, E., Wilson, I.D. (eds) Drug Determination in Therapeutic and Forensic Contexts. Methodological Surveys in Biochemistry and Analysis, vol 14. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2397-6_15

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  • DOI: https://doi.org/10.1007/978-1-4613-2397-6_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9462-7

  • Online ISBN: 978-1-4613-2397-6

  • eBook Packages: Springer Book Archive

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