Abstract
For suitable compounds, HPLC with electrochemical detection offers excellent sensitivity with relatively good selectivity; but accurate and reliable operation, particularly at levels of a few pmol, relies upon both correct selection and good matching of equipment and its operation. Often the detection of trace compounds requires the instrumentation to give satisfactory results at signal-to-noise ratios of below 10 at fmol levels. The ability of some commercially available detectors, a number of different pumps, and various electrodes to meet these requirements has been investigated in connection with measuring the levels in plasma of catecholamines and a number of thiols including thiol drugs.
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© 1984 Plenum Press, New York
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Perrett, D. (1984). Comparative Performance of Different HPLC Systems with Electrochemical Detection. In: Reid, E., Wilson, I.D. (eds) Drug Determination in Therapeutic and Forensic Contexts. Methodological Surveys in Biochemistry and Analysis, vol 14. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2397-6_14
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DOI: https://doi.org/10.1007/978-1-4613-2397-6_14
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