Skip to main content
SpringerLink
Log in

TLC as a Pilot Technique for Reversed-Phase HPLC

  • Chapter
Drug Determination in Therapeutic and Forensic Contexts

Part of the book series: Methodological Surveys in Biochemistry and Analysis ((ANAY,volume 14))

  • 237 Accesses

Abstract

Studies now presented have shown that the RP-HPLC behaviour of test solutes correlates well with TLC on alkyl-bonded silica if the mobile phase contains only water and an organic modifier, but less well if it contains an ion-pair reagent and buffer. We have investigated conditions for getting an ion-pair effect in RP-TLC.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Issaq, H.J., Shaikh, B., Pontzer, N.J. & Barr, E.W. (1978) J. Liq. Chromatog. 1, 133 – 149.

    Article  CAS  Google Scholar 

  2. Jork, H. & Wimmer, H. (1981) GIT Fachz. Lab. 7, 566 – 573

    Google Scholar 

  3. Bieganowska, M. & Soczewiński, E. (1981) J. Chromatog. 205, 451 – 456.

    Article  CAS  Google Scholar 

  4. Golkiewicz, W.(1981) Chromatographia l4, 629–632.

    Article  CAS  Google Scholar 

  5. Okumura, T. (1981) J. Liq. Chromatog. 4, 1035–1064.

    Article  CAS  Google Scholar 

  6. Guinchard, C., Masson, J.D., Truong, T.T. & Porthault, M. (1982) J. Liq. Chromatog. 5, 1123 – 1140.

    Article  CAS  Google Scholar 

  7. Issaq, H.J., Klose, J.R. & Reitz, G.A. (1982) J. Liq. Chromatog. 5, 1069 – 1080.

    Article  CAS  Google Scholar 

  8. Brinkman, U.A. Th. & de Vries, G. (1982) J. High Resol. Chromatog. Chromatog. Comm. 5, 476 – 482.

    Article  CAS  Google Scholar 

  9. Brinkman, U.A. Th., de Vries, G. & Cuperus, R. (1980) J. Chromatog. 198, 421 - 428.

    Article  CAS  Google Scholar 

  10. Lepri, L., Desideri, P.G. & Heimler, D. (1978) J. Chromatog. 153, 77 – 82.

    Article  CAS  Google Scholar 

  11. Volkmann, D. (1979) as for 8., 2, 729–732.

    Google Scholar 

  12. Gonnet, C., Marichy, M. & Naghizadeh, H. (198O) in Recent Developments in Chromatography and Electrophoresis, Vol. 10 (Frigerio, A.& McCamish, M., eds.), Elsevier, Amsterdam, pp. 11–19

    Google Scholar 

  13. Ogan, K. & Katz, E. (1980) J. Chromatog. 188, 115 – 127.

    Article  CAS  Google Scholar 

  14. Amos, R. (1981) J. Chromatog. 204, 469–478.

    Article  CAS  Google Scholar 

  15. Panthananickal, A. & Marnett, L.J. (1981) J. Chromatog. 206, 253 – 265.

    Article  CAS  Google Scholar 

  16. Goldberg, A.P. (1982) Anal. Chem. 54, 343 – 345.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Research Laboratories, Duphar, P.O. Box 2, 1380 AA, Weesp, The Netherlands

    N. Lammers, J. Zeeman & G. J. de Jong

  2. Department of Analytical Chemistry, Free University, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands

    U. A. Th. Brinkman

Authors
  1. N. Lammers
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Zeeman
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. J. de Jong
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. U. A. Th. Brinkman
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Guildford Academic Associates, Guildford, Surrey, UK

    Eric Reid

  2. Hoechst Pharmaceutical Research Laboratories, Milton Keynes, UK

    Ian D. Wilson

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Plenum Press, New York

About this chapter

Cite this chapter

Lammers, N., Zeeman, J., de Jong, G.J., Brinkman, U.A.T. (1984). TLC as a Pilot Technique for Reversed-Phase HPLC. In: Reid, E., Wilson, I.D. (eds) Drug Determination in Therapeutic and Forensic Contexts. Methodological Surveys in Biochemistry and Analysis, vol 14. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2397-6_13

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2397-6_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9462-7

  • Online ISBN: 978-1-4613-2397-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation