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Pathogenesis of Valve Calcification

Comparison of Three Tissue Valves
  • Hiroaki Harasaki
  • James T. McMahon
  • Nose Yukihiko

Abstract

Since glutaraldehyde was introduced in preservation of tissue valve prostheses in 1969 [5], the durability of these valves has greatly improved. However, the problem of degeneration and calcification continues to complicate the use of various glutaraldehyde-fixed tissue valves [2,3,7,9,10,15,16,18,22,25], especially following implantation in children and adolescents [4,6,8,11,17,24,26-28]. In the younger patient group, it is indicated that less than 50% of valves remain functional after 5 years of implantation [6]. Elevated heart rate and calcium turnover appear to be the causative factors in early calcification, although no clear- cut evidence has been offered. Renal failure may also render the patient more vulnerable to calcific complication [9,15,17,19], although its etiology has not been established.

Keywords

Aortic Valve Valve Replacement Tissue Valve Left Valve Valve Calcification 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Hiroaki Harasaki
    • 1
  • James T. McMahon
    • 2
  • Nose Yukihiko
    • 1
  1. 1.Department of Artificial OrgansCleveland Clinic FoundationClevelandUSA
  2. 2.Department of PathologyCleveland Clinic FoundationClevelandUSA

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