Hormonal Regulation of Phosphoinositide Metabolism in Rat Hepatocytes

  • John N. Fain
  • Michael Wallace
  • Sue-Hwa Lin
  • Irene Litosch


This chapter reviews recent advances on the hormonal regulation of phosphoinositide metabolism in rat hepatocytes. The pioneering work of Hokin and Hokin on pancreatic slices demonstrated that acetylcholine stimulated the uptake of 32P into phosphatidic acid and phosphatidylinositol (PI) but not into other phospholipids [1]. Durell et al. [2] suggested that the increased turnover of PI and phosphatidic acid was secondary to an initial hormone-stimulated breakdown of PI.


Phosphatidic Acid Glycogen Phosphorylase Hepatocyte Plasma Membrane Phosphoinositide Metabolism Glycogen Phosphorylase Activity 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • John N. Fain
    • 1
  • Michael Wallace
    • 1
  • Sue-Hwa Lin
    • 1
  • Irene Litosch
    • 1
  1. 1.Section of Biochemistry, Division of Biology and MedicineBrown UniversityProvidenceUSA

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