Factors Influencing Calcium Balance in Man

  • Herta Spencer
  • Lois B. Kramer

Abstract

Calcium balance studies are time-consuming and tedious to perform. They also require strictly controlled study conditions, namely a constant dietary intake, completeness of collections of excreta, analyses of calcium intake as well as urinary and fecal excretions. These balances have to be determined for relatively long periods of time in order to obtain interpretable data because of the time required for adaptation to a given calcium intake. Another reason for employing long-term balance studies is the fact that passage of minerals, including calcium, through the intestine may be considerably delayed [2,38]. Despite these difficulties and the unavoidable errors inherent in determining calcium balances, the state of calcium metabolism can be quite reliably assessed by determining the intake and excretion of calcium in urine and stool. The loss of calcium in sweat is usually not monitored, and calcium balances must therefore be considered as maximal values.

Keywords

Zinc Phosphorus Magnesium Osteoporosis Fluoride 

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References

  1. 1.
    Albanese, A. A. Principles and applications for nutrition and diet in aging. In Handbook of Geriatric Nutrition, J. M. Hsu and R. L. Davis, eds., Park Ridge, N.J., Noyes Publications, 1981, pp. 219–249.Google Scholar
  2. 2.
    Albright, F.; Reifenstein, E. D., Jr. The Parathyroid Glands and Metabolic Bone disease, Baltimore, Williams, Wilkins, 1948.Google Scholar
  3. 3.
    Allen, L. H. Calcium bioavailability and absorption: A review. Am. J. Clin. Nutr 35: 783–808, 1982.PubMedGoogle Scholar
  4. 4.
    Arem, J. H.; Misiorowski, R. Lathyritic activity of isoniazid. J. Med. (N.Y.) 7: 239–248, 1976.Google Scholar
  5. 5.
    Aub, J. C.; Bauer, W.; Heath, C.; Ropes, M. Studies of calcium and phosphorus metabolism. III. The effects of the thyroid hormone and thyroid disease. J. Clin. Invest 7: 97–137, 1929.PubMedCrossRefGoogle Scholar
  6. 6.
    Bell, R. R.; Engelman, D. T.; Sie, T.; Draper, H. H. Effect of a high protein intake on calcium metabolism in the rat. J. Nutr 105: 475–483, 1975.PubMedGoogle Scholar
  7. 7.
    Calvo, M. S.; Bell, R. R.; Forbes, R. M. Effect of protein-induced calciuria on calcium metabolism and bone status in adult rats. J. Nutr 112: 1401–1413, 1982.PubMedGoogle Scholar
  8. 8.
    Cook, P. B.; Nassim, J. R.; Collins, J. The effects of thyrotoxicosis upo% the metabolism of calcium, phosphorus, and nitrogen. Q. J. Med. 28:505–529, 1959.PubMedGoogle Scholar
  9. 9.
    Deitrick, J. E.; Whedon, G. D.; Shorr, E. Effects of immobilization upon various metabolic and physiologic functions of normal men. Am. J. Med 4: 3–36, 1948.PubMedCrossRefGoogle Scholar
  10. 10.
    Donaldson, C. L.; Hulley, S. B.; Vogel, J. M.; Hattner, R. S.; Bayers, J. H.; McMillian, D. E. Effect of prolonged bed rest on bone mineral. Metabolism 19: 1071–84, 1970.PubMedCrossRefGoogle Scholar
  11. 11.
    Draper, H. H.; Scythes, C. A. Calcium, phosphorus, and osteoporosis. Fed. Proc 40: 2434–2438, 1981.Google Scholar
  12. 12.
    Fiske, C. H.; SubbaRow, Y. T. The colorimetric determination of phosphorus. J. Biol. Chem 66: 375–400, 1925.Google Scholar
  13. 13.
    Forbes, G. B. Another source of error in the metabolic balance method. Nutr. Rev 31: 297, 1973.CrossRefGoogle Scholar
  14. 14.
    Goldsmith, R. S.; Ingbar, S. H. Inorganic phosphate treatment of hypercalcemia of diverse etiologies. N. Engl. J. Med 274: 1–7, 1966.CrossRefGoogle Scholar
  15. 15.
    Heaney, R. P.; Gallagher, J. C.; Johnston, C. C.; Neer, R.; Parfitt, A. M.; Whedon, G. D. Calcium nutrition and bone health in the elderly. Am. J. Clin. Nutr 36: 986–1013, 1982.Google Scholar
  16. 16.
    Heaney, R. P.; Recker, R. R. Effects of nitrogen, phosphorus, and caffeine on calcium balance in women. J. Lab. Clin. Med 99: 46–55, 1982.Google Scholar
  17. 17.
    R. P.; Recker, R. R.; Saville, P. D. Calcium balance and calcium requirements in middle-aged women. Am. J. Clin. Nutr 30: 1603–1611, 1977.Google Scholar
  18. 18.
    Hegsted, D. M. Mineral intake and bone loss. Fed. Proc 26: 1747–1754, 1967.Google Scholar
  19. 19.
    Hegsted, M.; Linkswiler, H. M. Long-term effects of level of protein intake on calcium metabolism in young adult women. J. Nutr 111: 244–251, 1981.Google Scholar
  20. 20.
    Hegsted, D. M.; Moscosco, I.; Collazos. C. H. C. Study of minimum calcium requirements by adult men. J. Nutr 46: 181–201, 1952.Google Scholar
  21. 21.
    Irwin, M. I.; Kienholz, E. W. A conspectus of research on calcium requirements of man. J. Nutr 103: 1019–1095, 1973.Google Scholar
  22. 22.
    Isaksson, B.; Sjorgren, B. A critical evaluation of the calcium balance technique. I. Variation in fecal output. Metabolism 16: 295–302, 1967.CrossRefGoogle Scholar
  23. 23.
    Linkswiler, H. M.; Zemel, M. B.; Hegsted, D. M.; Schuette, S. Protein-induced hypercalciuria. Fed. Proc 40: 2429–2433, 1981.Google Scholar
  24. 24.
    Lotz, M.; Zisman, E.; Bartter, F. C. Evidence for a phosphorus-depletion syndrome in man. N. Engl. J. Med 278: 409–415, 1968.CrossRefGoogle Scholar
  25. 25.
    Lukert, B. P.; Adams, J. S. Calcium and phosphorus homeostasis in man: Effect of corticosteroids. Arch. Intern. Med 136: 1249–1253, 1976.CrossRefGoogle Scholar
  26. 26.
    Malm, O. J. On phosphates and phosphoric acid as dietary factors in the calcium balance of man. Scand. J. Clin. Lab. Invest 5: 75–84, 1953.CrossRefGoogle Scholar
  27. 27.
    Nonomura, E.; Okamoto, M.; Sobue, S.; Moriwaki, Y. X-ray microbeam diffraction analyses on a tooth discolored by tetracycline. J. Dent. Res 56: 447–450, 1977.CrossRefGoogle Scholar
  28. 28.
    Oberleas, D.; Muhrer, M. E.; O’Dell, B. L. Effects of phytic acid on zinc availability and parakeratosis in swine. J. Anim. Sci 21: 57–61, 1962.Google Scholar
  29. 29.
    O’Dell, B. L.; Savage, J. E. Effect of phytic acid on zinc availability. Proc. Soc. Exp. Biol. Med 103: 304–306, 1960.Google Scholar
  30. 30.
    Pecoud, A.; Donzel, P.; Schelling, J. L. Effect of foodstuffs on the absorption of zinc sulfate. Clin Pharmacol. Ther 17: 469–474, 1975.Google Scholar
  31. 31.
    Pronove, P.; Bell, N. H.; Bartter, F. C. Production of hypercalciuria by phosphorus deprivation on a low calcium intake: A new clinical test for hyperparathyroidism. Metabolism 10: 364–371, 1961.Google Scholar
  32. 32.
    Recommended dietary allowances, 8th rev. ed., Washington, D.C., National Academy of Sciences, 1980.Google Scholar
  33. 33.
    Rich, C.; Ensinck, J.; Ivanovich, P. The effects of sodium fluoride on calcium metabolism of subjects with metabolic bone diseases. J. Clin. Invest 43: 545–556, 1964.CrossRefGoogle Scholar
  34. 34.
    Schuette, S. A.; Linkswiler, H. M. Effects on Ca and P metabolism in humans by adding meat, meat plus milk, or purified proteins plus Ca and P to a low protein diet. J. Nutr 112: 338–349, 1982.Google Scholar
  35. 35.
    Schuette, S. A.; Zemel, M. B.; Linkswiler, H. M. Studies on the mechanism of protein-induced hypercalciuria in older men and women. J. Nutr 110: 305–315, 1980.Google Scholar
  36. 36.
    Schwartz, R.; Woodcock, N. A.; Blakely, J. D.; MacKellar, I. Metabolic responses of adolescent boys to two levels of dietary magnesium and protein. II. Effect of magnesium and protein level on calcium balance. Am. J. Clin. Nutr 26: 519–523, 1973.Google Scholar
  37. 37.
    Spencer, H. Osteoporosis: Goals of therapy. Hosp. Pract 17: 131–151, 1982.Google Scholar
  38. 38.
    Spencer H.; Friedland, J. A.; Ferguson, V. Human balance studies in mineral metabolism. In: Biological Mineralization, I. Zipkin, ed., New York, Wiley, 1973, pp. 689–727.Google Scholar
  39. 39.
    Spencer, H.; Kramer, L.; DeBartolo, M.; Norris, C.; Osis, D. Further studies of the effect of a high protein diet as meat on calcium metabolism. Am. J. Clin. Nutr 37: 924–929, 1983.Google Scholar
  40. 40.
    Spencer, H.; Kramer, L.; Norris, C.; Osis, D. Effect of small doses of aluminum-containing antacids on calcium and phosphorus metabolism. Am. J. Clin. Nutr 36: 32–40, 1982.Google Scholar
  41. 41.
    Spencer, H.; Kramer, L.; Osis, D. Zinc balances in humans. In: Clinical, Biochemical and Nutritional Aspects of Trace Elements, A. S. Prasad, ed., New York, Liss, 1982, pp. 103–115.Google Scholar
  42. 42.
    Spencer, H.; Kramer, L.; Osis, D. Factors contributing to calcium loss in aging. Am. J. Clin. Nutr 36: 776–787, 1982.Google Scholar
  43. 43.
    Spencer, H.; Kramer, L.; Osis, D.; Norris, C. Effect of a high protein (meat) intake on calcium metabolism in man. Am. J. Clin. Nutr 31: 2167–2180, 1978.Google Scholar
  44. 44.
    Spencer, H.; Kramer, L.; Osis, D.; Norris, C. Effect of phosphorus on the absorption of calcium and on the calcium balance in man. J. Nutr 108: 447–457, 1978.Google Scholar
  45. 45.
    Spencer, H.; Lewin, I.; Osis, D.; Samachson, J. Studies of fluoride and calcium metabolism in patients with osteoporosis. Am. J. Med 49: 814–822, 1970.CrossRefGoogle Scholar
  46. 46.
    Spencer, H.; Osis, D.; Kramer, L. Metabolic effects of pharmacologic doses of zinc in man. Am. J. Clin. Nutr 30: 611, 1977.Google Scholar
  47. 47.
    Walker, P. M.; Linkswiler, H. M. Calcium retention in the adult human male as affected by protein intake. J. Nutr 102: 1297–1302, 1972.Google Scholar
  48. 48.
    Whedon, G. D.; Shorr, E. Metabolic studies in paralytic acute anterior poliomyelitis. II. Alterations in calcium and phosphorus metabolism. J. Clin. Invest 36: 966–981, 1957.CrossRefGoogle Scholar
  49. 49.
    Whiting, S. J.; Draper, H. H. Effect of chronic high protein feeding on bone composition in the adult rat. J. Nutr 111: 178–183, 1981.PubMedGoogle Scholar
  50. 50.
    Willis, J. B. Determination of metals in blood serum by atomic absorption spectroscopy. I. Calcium. II. Magnesium. Spectrochim. Acta 16: 259–272, 1960.CrossRefGoogle Scholar
  51. 51.
    Willis, J. B. Determination of calcium and magnesium in urine by atomic absorption spectroscopy. Anal. Chem 33: 556 - 559, 1961.CrossRefGoogle Scholar
  52. 52.
    World Health Organization Technical Report Series No. 230. Calcium requirements, Geneva, WHO, 1962, pp. 16–18.Google Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Herta Spencer
    • 1
  • Lois B. Kramer
    • 1
  1. 1.Metabolic SectionVeterans Administration HospitalHinesUSA

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