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Platelet Response in Relation to Metabolism of Inositides and Protein Phosphorylation

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Calcium in Biological Systems

Abstract

In the last few years our work has concentrated on lipid changes associated with platelet responses. We found initially that phosphatidic acid is rapidly formed in thrombin-stimulated platelets due to the breakdown of inositol phospholipids [1]. A specific phospholipase C degrades inositol phospholipids, and the 1,2-diacylglycerol so formed is phosphorylated to phosphatidic acid by 1,2-diacylglycerol kinase. The time course for the formation of phosphatidic acid differs from that for liberation of arachidonic acid from various phospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, and also phosphatidic acid by phospholipase A2. This suggested a sequential stimulation of phospholipase C and phospholipases A2 [1,2].

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Author information

Author notes

  1. Wolfgang Siess

    Present address: Medizinische Klinik Innenstadt, Universität München, 8 Munich 2, West Germany

Authors and Affiliations

  1. Department of Molecular Biology, The Wellcome Research Laboratories, Burroughs Wellcome Company, Research Triangle Park, North Carolina, 27709, USA

    Eduardo G. Lapetina & Wolfgang Siess

Authors
  1. Eduardo G. Lapetina
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  2. Wolfgang Siess
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Editor information

Editors and Affiliations

  1. Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA

    Ronald P. Rubin  & James W. Putney Jr.  & 

  2. CIBA-GEIGY Corporation, Summit, New Jersey, USA

    George B. Weiss

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© 1985 Plenum Press, New York

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Lapetina, E.G., Siess, W. (1985). Platelet Response in Relation to Metabolism of Inositides and Protein Phosphorylation. In: Rubin, R.P., Weiss, G.B., Putney, J.W. (eds) Calcium in Biological Systems. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2377-8_5

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  • DOI: https://doi.org/10.1007/978-1-4613-2377-8_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9453-5

  • Online ISBN: 978-1-4613-2377-8

  • eBook Packages: Springer Book Archive

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