Calcium and Myogenic or Stretch-Dependent Vascular Tone

  • John A. Bevan
  • Joyce J. Hwa
  • Mary P. Owen
  • Raymond J. Winquist

Abstract

Peripheral vascular bed resistance and capacitance is related not only to the architecture and passive physical properties (both relatively static components) of the bed, but also to the active vascular tone of its component blood vessels. This tone may be extrinsic or intrinsic in origin. Extrinsic tone results from influences that originate outside the smooth muscle cells, such as circulating vasoactive substances and locally released material from such cellular elements as neurons, mast cells, and platelets. Intrinsic tone, on the other hand, is considered to originate from within the smooth muscle cells themselves. This may not be a useful classification since all evidence suggests that myogenic (intrinsic) tone appears in response to stretch. Perhaps a classification of tone based on its primary cause would be more satisfactory.

Keywords

Permeability Nitrite Norepinephrine Calorimetry Cardiol 

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • John A. Bevan
    • 1
  • Joyce J. Hwa
    • 1
  • Mary P. Owen
    • 1
  • Raymond J. Winquist
    • 2
  1. 1.Department of Pharmacology, School of MedicineUniversity of VermontBurlingtonUSA
  2. 2.Cardiovascular PharmacologyMerck Sharp & Dohme Research LaboratoriesWest PointUSA

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