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Role of Calcium in Heart Function in Health and Disease

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Calcium in Biological Systems

Abstract

In his experiments on isolated frog hearts, Ringer [34] first reported that “saline solution, to which is added one ten-thousandth part of potassium chloride, makes an excellent circulating fluid in experiments with the detached heart.” However, in these misleading experiments, the saline solution (0.75 NaCl) was prepared with pipe water contaminated with traces of many inorganic salts including Ca2 +. When Ringer repeated these experiments with all solutions made using distilled water [35], he discovered that Ca2+ has an important role in heart function.

A small quntity of calcium, added to saline solution with small amounts of potassium chloride, makes a good artificial circulating fluid ans the ventricle will continue beating perfectly for more than four hours [Sydney Ringer, 1883].

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Author information

Authors and Affiliations

  1. Experimental Cardiology Section, Department of Pysiology, University of Manitoba, Winnipeg, R3E OW3, Manitoba, Canada

    Pawan K. Singal, Robert E. Beamish & Naranjan S. Dhalla

  2. Department of Oral Biology, University of Manitoba, Winnipeg, R3E OW3, Manitoba, Canada

    Vincenzo Panagia

Authors
  1. Pawan K. Singal
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  2. Vincenzo Panagia
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  3. Robert E. Beamish
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  4. Naranjan S. Dhalla
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Editors and Affiliations

  1. Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA

    Ronald P. Rubin  & James W. Putney Jr.  & 

  2. CIBA-GEIGY Corporation, Summit, New Jersey, USA

    George B. Weiss

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© 1985 Plenum Press, New York

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Singal, P.K., Panagia, V., Beamish, R.E., Dhalla, N.S. (1985). Role of Calcium in Heart Function in Health and Disease. In: Rubin, R.P., Weiss, G.B., Putney, J.W. (eds) Calcium in Biological Systems. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2377-8_40

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  • DOI: https://doi.org/10.1007/978-1-4613-2377-8_40

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9453-5

  • Online ISBN: 978-1-4613-2377-8

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