Abstract
Calcineurin, a major calmodulin-binding protein of brain [15], was initially identified as a heat-labile inhibitor of calmodulin-stimulated cyclic nucleotide phosphodiesterase [17,36]. Although the function of this protein was not known, because of its Ca2+ -binding properties [15] and its apparent neural localization [34], it was named calcineurin [15]. The recent discovery of a calmodulin-stimulated protein phosphatase with similar subunit structure [29] led to the identification of calcineurin as a phosphoprotein phosphatase [30]. Calcineurin subunit interactions can now be correlated with observed regulatory properties of the en¬zyme, providing the opportunity to explore the relationship between subunit structure and the mechanisms of phosphatase regulation.
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© 1985 Plenum Press, New York
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Manalan, A.S., Klee, C.B. (1985). Calcineurin, a Calmodulin-Stimulated Protein Phosphatase. In: Rubin, R.P., Weiss, G.B., Putney, J.W. (eds) Calcium in Biological Systems. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2377-8_35
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DOI: https://doi.org/10.1007/978-1-4613-2377-8_35
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