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Calcium-Activated Potassium Channels in Bullfrog Sympathetic Ganglion Cells

  • Chapter
Calcium in Biological Systems

Abstract

The existence of a calcium activated potassium current (Ic) in the somata of vertebrate sympathetic ganglion cells was postulated to account for the calcium-sensitive spike after-hyperpolarizations present in these cells [19,22,26]. We have studied Ic in bullfrog ganglion cells more directly by using various voltage-clamp techniques, partly in order to understand better the role this current plays in spike repolarization, spike afterhyperpolarization, and spontaneous hyperpolarizations, and partly to define the difference between Ic and the M-current Im [4]. Both Ic and Im are voltage-sensitive potassium currents sensitive to transmitters, the former being activated by internal calcium and the latter inactivated by external acetylcholine. Despite these superficial similarities, it turns out that the two currents have virtually nothing in common.

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Author information

Authors and Affiliations

  1. Department of Neurobiology and Behavior, State University of New York, Stony Brook, New York, 11794, USA

    Paul R. Adams & Leslie Satin

  2. Department of Pharmacology, School of Pharmacology, London, WCIN IAX, England

    David A. Brown & Andrew Constanti

  3. Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston, Texas, 77550, USA

    Robert B. Clark

Authors
  1. Paul R. Adams
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  2. David A. Brown
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  3. Andrew Constanti
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  4. Robert B. Clark
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  5. Leslie Satin
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Editor information

Editors and Affiliations

  1. Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA

    Ronald P. Rubin  & James W. Putney Jr.  & 

  2. CIBA-GEIGY Corporation, Summit, New Jersey, USA

    George B. Weiss

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© 1985 Plenum Press, New York

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Adams, P.R., Brown, D.A., Constanti, A., Clark, R.B., Satin, L. (1985). Calcium-Activated Potassium Channels in Bullfrog Sympathetic Ganglion Cells. In: Rubin, R.P., Weiss, G.B., Putney, J.W. (eds) Calcium in Biological Systems. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2377-8_21

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  • DOI: https://doi.org/10.1007/978-1-4613-2377-8_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9453-5

  • Online ISBN: 978-1-4613-2377-8

  • eBook Packages: Springer Book Archive

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