Abstract
Alterations in cation fluxes across the plasma membrane appear to play a central role in the regulation of cellular growth and differentiation [1,2,4,6–8,17,19]. Oocyte maturation is stimulated by Ca2+ release into the cytoplasm [7], and serum factors which stimulate growth of quiescent cells in culture cause rapid changes in Na+, H+, Ca2+, and K+ fluxes across the plasma membrane [4,8,17]. However, it has not been conclusively demonstrated that these changes in cation fluxes are essential for the subsequent acceleration of growth. In this context, a limited number of established cell lines, which are capable of undergoing differentiation in culture, provide an opportunity for investigating the role of cation fluxes in growth regulation and signaling terminal differentiation.
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References
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© 1985 Plenum Press, New York
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Cantley, L. et al. (1985). Na+ and Ca2+ Fluxes and Differentiation of Transformed Cells. In: Rubin, R.P., Weiss, G.B., Putney, J.W. (eds) Calcium in Biological Systems. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2377-8_20
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DOI: https://doi.org/10.1007/978-1-4613-2377-8_20
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