Abstract
The aggregation of receptors for IgE on the surface of mast cells and basophils leads to secretion of a variety of mediators of immediate hypersensitivity. Many of these mediators, including histamine and serotonin, are stored in granules within the cytoplasm, while others such as arachidonic acid and its metabolites (e. g., prostaglandins and leukotrienes) are newly formed when cells are stimulated to secrete. In common with other secretory systems, mast cell granule exocytosis is presumed to occur as a result of a rise in cytoplasmic free Ca2+ and is also dependent on a source of metabolic energy. The mechanism of IgE receptor activation and the events leading to exocytosis are beginning to be unraveled [1] and we now know a considerable amount about the molecular structure of the first component in the sequence, namely the receptor for IgE [2].
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© 1985 Plenum Press, New York
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Fewtrell, C. (1985). Activation and Desensitization of Receptors for IgE on Tumor Basophils. In: Rubin, R.P., Weiss, G.B., Putney, J.W. (eds) Calcium in Biological Systems. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2377-8_15
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DOI: https://doi.org/10.1007/978-1-4613-2377-8_15
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