The Multivariate Approach in Pharmaco-EEG and ERP Research

  • Guenter-Klaus Schenk


Pharmaco-EEGs conventionally are based on a small number of recording channels; a good deal of studies only utilized a single trace investigation for evidencing cerebral drug effects. Actually this is in strong favor of the pharmaco-EEG model (Schenk et al. 1982a); by a limited amount of information the major classes of psychotropic drugs could sufficiently be characterized in terms of quantitative drug efficacy profiles. Following this line reliable procedures for successfully classifying totally new compounds were established. In parallel a continuously imrproving computer technology substantially contributed to progress in pharmaco-EEG research. But, unfortunately, for a variety of— nonscientific — reasons large scale processing of EEG data was seriously hampered for many years. Since the recent availability of very powerful laboratory hardware this may now be changed rather dramatically: firstly, in-lab EDP capacity is available for a complete handling of huge data bodies and secondly, independency from central EDP services warrants tremendous savings in time.


Factor Score Graphic Factor Drug Influence Double Blind Crossover Design Counter Plot 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Guenter-Klaus Schenk
    • 1
  1. 1.Central Diagnostic Division, Dept. of PsychiatryRLHK, University HospitalEssenGermany

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