Abstract
Magee and Barnes(1) reported that dimethylnitrosamine (NDMA) caused liver tumors when fed to rats. Ender and colleagues(2) reported that toxic herring meal contained NDMA and they speculated that the nitrosamine arose from the reaction of sodium nitrite and the methyl amines present in fish meal. N-Nitrosamines (NAs) are now known to be a widely acting group of animal carcinogens(3) and are found, usually at trace levels, in many diverse places in the environment, such as: nitrite- cured meats, polluted air, tobacco smoke, cutting oils, hydraulic fluids, cosmetics, herbicides, pharmaceuticals, beer, Scotch whiskey, and rubber products. This is not to say that nitrosamines will always be found in the sources listed, and it should be noted that due to research and subsequent corrective action, the levels of volatile nitrosamines have been reduced in certain products.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
P. N. Magee and J. M. Barnes, Br. J. Cancer 10, 114 (1956).
F. Ender, G. Harve, A. Helgebostad, N. Koppang, R. Madsen, and L. Ceh, Naturwis- senschaften 51, 637 (1964).
W. Lijinsky, in N-Nitrosamines ( J.-P. Anselme, ed.), American Chemical Society, Wash-ington, D.C., 1979, pp. 165–173.
T. Wang, T. Kakizoe, P. Dion, R. Furrer, A. J. Varghese, and W. R. Bruce, Nature 276, 280–281 (1978).
J. Collin, Bull. Soc. Roy. Sci. Liege 23, 201–220 (1954).
W. T. Rainey, W. H. Christie, and W. Lijinsky, Biomed. Mass Spectrom. 5, 395–408 (1978).
W. Lijinsky, W. H. Christie, and W. T. Rainey, Jr., Mass Spectra of N-nitroso Compounds, Oak Ridge Nat. Lab., Tech. Report No. TM-4359, 1973, pp. 1–106.
W. T. Rainey, W. H. Christie, C. A. Pritchard, and W. Lijinsky, Mass Spectra of N- Nitroso Compounds, Oak Ridge National Laboratory, Tech. Report No. TM-5500, 1976, pp. 1–63.
J. W. Pensabene, W. Fiddler, C.J. Dooley, R. C. Doerr, and A. E. Wasserman, J. Agric. Food Chem. 20, 274 (1972).
G. Schroll, R. G. Cooks, P. Klemmensen, and S.-O. Lawesson, Arkiv for Kemi 28, 413–422 (1968).
J. W. ApSimon and J. D. Cooney, Can.]. Chem. 49, 1367–1371 (1971).
M.J. Saxby J. Assoc. Off. Anal. Chem. 55, 9–12 (1972).
R. Self, Biomed. Mass Spectrom. 6, 361–373 (1979).
J. H. Hotchkiss, L. M. Libbey, and R. A. Scanlan, J. Assoc. Off. Anal. Chem. 63, 74–79 (1980).
K. S. Webb, T. A. Gough, A. Carrick, and D. Hazelby, Anal. Chem. 51, 989–992 (1979).
T. Fazio, R. H. White, L. R. Dusold, and J. W. Howard, J Assoc. Off. Anal. Chem. 56, 919–921 (1973).
L. M. Libbey and R. A. Scanlan, J. Assoc. Off. Anal. Chem. 64, 1255–1256 (1981).
S. R. Heller and G. W. A. Milne, EPA/NIH Mass Spectral Data Base, Department of Commerce, U.S. Government, Washington, D.C., 1978.
N. P. Sen, W. F. Miles, B. Donaldson, T. Panalaks, and J. R. Iyengar, Nature 245, 104 (1973).
D. P. Rounbehler,J. Reisch, and D. H. Fine, J. Food Cosmet. Toxicol 18, 147–151 (1980).
E. U. Goff, J. R. Coombs, D. H. Fine, and T. M. Baines, Anal. Chem. 52, 1833–1836 (1980).
T. Y. Fan, I. S. Krull, R. D. Ross, M. H. Wolf, and D. H. Fine, in Environmental Aspects ofN-nitroso Compounds, ( E. A. Walker, M. Castegnaro, L. Griciute, R. E. Lyle, and W. Davis, eds.), International Agency for Research on Cancer, Lyon, 1978, pp. 3–17.
C. Janzowski, G. Eisenbrand, and R. Preussmann, J. Chromatogr. 150, 216–220 (1978).
N. P. Sen, W. F. Miles, S. Seaman, and J. F. Lawrence, J. Chromatogr. 128, 169–173 (1976).
J. S. Lee, L. M. Libbey, R. A. Scanlan, and D. D. Bills, Bull. Environ. Contam. Toxicol. 19, 511–517 (1978).
J. S. Lee, D. D. Bills, R. A. Scanlan, and L. M. Libbey J. Agric. Food Chem. 25, 422–423 (1977).
T. Y. Fan, U. Goff, L. Song, D. H. Fine, G. P. Arsenault, and K. Biemann, J. Food Cosmet. Toxicol. 15, 423 (1977).
T. Y. Fan, J. Morrison, D. P. Roundehler, R. Ross, D. H. Fine, W. Miles, and N. P. Sen, Science 196, 170–171 (1977).
K. Heyns, S. Roper, H. Roper, and B. Meyer, Angew. Chem. Int. Ed. Engl. 18, 878–880 (1979).
D. H. Fine, F. Rufeh, D. Lieb, and D. P. Rounbehler, Anal. Chem. 47, 1188–1191 (1975).
T. A. Gough and K. Webb, in Environmental Carcinogens: Selected Methods of Analysis. Vol. 1. ( H. Egan, R. Preussmann, M. Castegnaro, E. A. Walker, and A. E. Wasserman, eds.), International Agency for Research on Cancer, Lyon, 1978, pp. 141–150.
R. A. Scanlan, R. G. Arnold, and R. C. Lindsay, J. Gas Chromatogr. 6, 372–373 (1968).
W. L. Budde and J. W. Eichelberger, Organics Analysis Using Gas Chromatography Mass Spectrometry, Ann Arbor Science, Ann Arbor, MI, 1979, pp. 35–37.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Plenum Press, New York
About this chapter
Cite this chapter
Libbey, L.M., Scanlan, R.A. (1985). Mass Spectrometry of N-Nitrosamines. In: Karasek, F.W., Hutzinger, O., Safe, S. (eds) Mass Spectrometry in Environmental Sciences. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2361-7_25
Download citation
DOI: https://doi.org/10.1007/978-1-4613-2361-7_25
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9445-0
Online ISBN: 978-1-4613-2361-7
eBook Packages: Springer Book Archive