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Anchoring and Biosynthesis of a Major Intrinsic Plasma Membrane Protein:The Sucrase—Isomaltase Complex of the Small-Intestinal Brush Border

  • Chapter
The Enzymes of Biological Membranes

Abstract

Aspects of the biochemistry and physiopathology of oligo- and disaccharidases of the small-intestinal brush border membrane have been the object of previous reviews (Semenza, 1968, 1976, 1978, 1981a). I will concentrate here on the membrane positioning and anchoring, and on the biosynthesis and probable phylogeny of one of the major disaccharidases, i.e., the sucrase-isomaltase complex* (See also Semenza, 1979,a,b; 1981b; Semenza et al., 1983; Brunner et al., 1983; Hauser and Semenza, 1983).

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Abbreviations

S:

sucrase

I:

isomaltase

SI:

sucrase-isomaltase

TID:

3-trifluoromethyl-3-(m[125I]iodophenyl)diazirine

DAP:

3-(dimethyl-2-(acetimidoxyethyl)ammonio)propanesulfonate

DOC:

deoxycholate

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Authors and Affiliations

  1. Laboratorium für Biochemie der ETH, ETH-Zentrum, CH-8092, Zürich, Switzerland

    Giorgio Semenza

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  1. State University of New York, Syracuse, New York, USA

    Anthony N. Martonosi

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Semenza, G. (1985). Anchoring and Biosynthesis of a Major Intrinsic Plasma Membrane Protein:The Sucrase—Isomaltase Complex of the Small-Intestinal Brush Border. In: Martonosi, A.N. (eds) The Enzymes of Biological Membranes. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2355-6_10

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  • DOI: https://doi.org/10.1007/978-1-4613-2355-6_10

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