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RES Function in Experimental and Human Liver Disease

  • Chapter
The Reticuloendothelial System

Abstract

The liver is not only a metabolic organ, but it is also an organ of great immunological function (Thomas et al., 1973; Bradfield, 1974; Triger, 1976). Gates et al. (1961) determined that only 78.8 to 84.2% of total liver cells are represented by hepatocytes and 14.7 to 16.6% by littoral cells including Kupffer cells. It is estimated that approximately 90% of total phagocytic capacity of the RES is provided by the liver (van Furth, 1970). These facts suggest that in liver and other gastrointestinal diseases RE function may become altered, a situation that may have harmful consequences for the organism (Liehr, 1982). Alternatively, it has to be clarified whether a functionally and/or anatomically altered liver RE system contributes to the liver pathology itself or even is the reason that liver injury develops.

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Authors and Affiliations

  1. Medical Department I, Academic Hospital, Saabrücken-Winterberg, West Germany

    Heinrich Liehr

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  1. Heinrich Liehr
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Editors and Affiliations

  1. University of South Florida, Tampa, Florida, USA

    Herman Friedman

  2. Medical College of Virginia, Richmond, Virginia, USA

    Mario Escobar

  3. Medical College of Georgia, Augusta, Georgia, USA

    Sherwood M. Reichard

  4. Loyola University Medical Center, Maywood, Illinois, USA

    James P. Filkins

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Liehr, H. (1985). RES Function in Experimental and Human Liver Disease. In: Friedman, H., Escobar, M., Reichard, S.M., Filkins, J.P. (eds) The Reticuloendothelial System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2353-2_9

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  • DOI: https://doi.org/10.1007/978-1-4613-2353-2_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9441-2

  • Online ISBN: 978-1-4613-2353-2

  • eBook Packages: Springer Book Archive

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