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Regulation of Complement Synthesis in Mononuclear Phagocytes

  • Chapter
The Reticuloendothelial System

Abstract

The complement system is comprised of at least 20 distinct normal serum proteins, which are capable of interacting with each other, with antibody, and with cell membranes (Porter and Reid, 1978). These interactions lead to the generation of biological activities, which mediate the inflammatory response. Advances in tissue and cell culture techniques and methods for quantitation of individual serum components have made it possible to study the biosynthesis of complement proteins in vitro. The major sites for production of the proteins in the complement system are parenchymal cells of the liver, transitional epithelial cells of the gastrointestinal and genitourinary tracts, and mononuclear phagocytes. Early studies (Ehrlich and Morganroth, 1900; Rice et al., 1951) suggested that the liver was the principal site of synthesis for serum complement components. This was confirmed to a great extent when it was shown for C3, C6, C8, and factor B that orthotopic liver transplantation from a donor with a distinct genetic variant of the relevant proteins resulted in complete conversion of the serum complement from recipient to donor allotype (Alper and Nathan, 1981). This means that at least 90% of the serum C3, C6, C8, and factor B is synthesized in the liver. Epithelial cells of the gastrointestinal and genitourinary tracts produce all three subcomponents of Cl, Clq, Clr, and Cls (Morris et al.,) and are probably responsible for a major portion of the serum Cl.

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Authors and Affiliations

  1. Department of Pediatrics, National Jewish Hospital and Research Center/National Asthma Center, USA

    Robert C. Strunk

  2. Department of Pediatrics, University of Colorado Medical School, Denver, Colorado, 80206, USA

    Robert C. Strunk

  3. Division of Cell Biology, Department of Medicine, Children’s Hospital Medical Center, USA

    Harvey R. Colten

  4. Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, O2115, USA

    Harvey R. Colten

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  1. Robert C. Strunk
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Editors and Affiliations

  1. University of South Florida, Tampa, Florida, USA

    Herman Friedman

  2. Medical College of Virginia, Richmond, Virginia, USA

    Mario Escobar

  3. Medical College of Georgia, Augusta, Georgia, USA

    Sherwood M. Reichard

  4. Loyola University Medical Center, Maywood, Illinois, USA

    James P. Filkins

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© 1985 Plenum Press, New York

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Strunk, R.C., Colten, H.R. (1985). Regulation of Complement Synthesis in Mononuclear Phagocytes. In: Friedman, H., Escobar, M., Reichard, S.M., Filkins, J.P. (eds) The Reticuloendothelial System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2353-2_2

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  • DOI: https://doi.org/10.1007/978-1-4613-2353-2_2

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