Endocrinelike Activities of the RES

An Overview
  • Robert N. Moore
  • L. Joe Berry


Numerous findings during the past decade have identified an impressive secretory capacity of the phagocytic cells of the reticuloendothelial system (RES). Macrophages in vitro have been found to secrete a variety of potent hormonelike mediators that influence or regulate activities of a variety of other cell types as well as other cellular components of the RES. In many cases, a direct correlation can be made between in vitro findings and established events occurring in vivo during infection or inflammatory responses, reaffirming the importance of the RES in a variety of host-microbial interactions. Of necessity, these mediators have been defined by their in vitro functional activities. As a result, there has been an accumulation of seemingly unrelated data concerning a dramatic number of different mediators. Recent studies, however, indicate that the actual number of different mediators produced by monocytes and macrophages is more limited than that suggested by the available literature. Investigations designed to characterize and to isolate specific mediators have shown that several are in fact the same molecules with multiple functional activities.


Murine Macrophage Serum Amyloid Muramyl Dipeptide Endogenous Pyrogen Nonlymphoid Cell 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Robert N. Moore
    • 1
  • L. Joe Berry
    • 2
  1. 1.Department of MicrobiologyThe University of TennesseeKnoxvilleUSA
  2. 2.Department of MicrobiologyThe University of TexasAustinUSA

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