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Persistent Renal-Genitourinary Disorders pp 217–226Cite as

Lipid Changes in Children on Dialysis

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Part of the book series: Developments in Nephrology ((DINE,volume 17))

Abstract

Hyperlipidemia (mainly with elevated triglyceride levels) is a frequent finding in uremic patients on dialysis. The reported incidence of hypertriglyceridemia in adults with end stage renal disease (ESRD), as well as in those patients undergoing chronic hemodialysis, varies from 30 to 70 percent (1). The predominant pattern of this hyperlipidemia is Type IV, consistent with an increase in total triglycerides (TG) and very low density lipoproteins (VLDL) with near normal total cholesterol (TC). Prospective epidemiologic studies in patients with and without renal disease indicate that the Type IV pattern is associated with an increased incidence of ischemic heart disease (2–3). The hyperlipidemia associated with uremia may begin in adults when creatinine clearance falls under 50 ml/min (4). It has been reported that hyperlipidemia in children also occur early in the course of chronic renal failure (CRF) when creatinine clearance falls below 40 ml/mln/1.73m2 (5). As renal function deteriorates serum triglyceride levels become significantly elevated and HDL levels markedly decrease, while serum total cholesterol, phospholipids and LDL remain essentially unchanged. These lipid abnormalities worsen further with the onset of hemodialysis (5).

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Authors
  1. Gaston Zilleruelo M.D
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  2. Milan Novak Ph.D
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  3. Michael Freundlich M.D
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  4. Carolyn Abitbol M.D
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  5. Jose Strauss M.D
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Editor information

Editors and Affiliations

  1. Division of Pediatric Nephrology, University of Miami School of Medicine, Miami, Florida, USA

    José Strauss MD

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© 1987 Martinus Nijhoff Publishing, Boston

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Zilleruelo, G., Novak, M., Freundlich, M., Abitbol, C., Strauss, J. (1987). Lipid Changes in Children on Dialysis. In: Strauss, J. (eds) Persistent Renal-Genitourinary Disorders. Developments in Nephrology, vol 17. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2339-6_20

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  • DOI: https://doi.org/10.1007/978-1-4613-2339-6_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-89838-845-9

  • Online ISBN: 978-1-4613-2339-6

  • eBook Packages: Springer Book Archive

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