Abstract
Epidemiologic and clinical studies. Atherosclerosis is a chronic disease process that begins early in life, progresses during young adulthood, and in middle age or later, an end-stage lesion develops that occludes the lumen of arteries, often leading to myocardial infarction, stroke, peripheral vascular disease or sudden death. A number of risk factors are associated with the development of atherosclerosis. These include age, sex (males on average develop complications of atherosclerosis 10 years younger than females), hypercholesterolemia, cigarette smoking, hypertension, diabetes mellitus, obesity, and a positive family history of premature atherosclerosis (1). An increased level of low density (beta) lipoproteins (LDL), the major carrier of plasma cholesterol, is strongly associated with coronary atherosclerosis; conversely, depressed levels of high density (alpha) lipoproteins (HDL) are independent risk factors for coronary atherosclerosis (1). Whether an increased plasma level of triglycerides, and their major carrier, very low density (prebeta) lipoproteins (VLDL) is a risk factor for atherosclerosis, independent of the other known factors, is controversial (2). In many families with premature coronary atherosclerosis, however, hypertriglyceridemia is prevalent (3).
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© 1987 Martinus Nijhoff Publishing, Boston
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Kwiterovich, P.O. (1987). Nutrition, Lipoproteins and Atherosclerosis in Childhood. In: Strauss, J. (eds) Persistent Renal-Genitourinary Disorders. Developments in Nephrology, vol 17. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2339-6_14
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DOI: https://doi.org/10.1007/978-1-4613-2339-6_14
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