Abstract
During the past decade, there has been considerable interest in the value of class I antiarrhythmic drugs for the prevention of ventricular fibrillation during the early hours of acute myocardial infarction. In animal studies a number of such drugs have been shown to prevent ventricular fibrillation following coronary artery ligation (1). However, only lidocaine has been studied extensively in randomized trials of the prevention of ventricular fibrillation in patients with suspected acute myocardial infarction. Eleven such trials (2–12) have been conducted involving a total of 8527 patients. There are only a few trials of the prophylactic effects of other class I drugs such as tocainide (13,14); the total number of patients studied in trials of these agents is too small to allow meaningful conclusions to be drawn about their effectiveness in the prevention of ventricular fibrillation.
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© 1987 Martinus Nijhoff Publishing, Boston
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MacMahon, S., Yusuf, S. (1987). Effects of Lidocaine on Ventricular Fibrillation, Asystole, and Early Death in Patients with Suspected Acute Myocardial Infarction. In: Califf, R.M., Wagner, G.S. (eds) Acute Coronary Care 1987. Acute Coronary Care Updates, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2337-2_4
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DOI: https://doi.org/10.1007/978-1-4613-2337-2_4
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