Abstract
The introduction of insulin therapy in 1922 represented survival for ketosis-prone diabetic patients, but survival at a cost. Over the ensuing years it became clear that with an increasing duration of insulin-dependent diabetes, vascular, and more specifically microvascular ‘complications’ occurred. Lundbaek (1) linked characteristic disease of the retina, kidney and distal peripheral vasculature, and the concept of microangiopathy emerged emphasising the microvascular nature of the complications. Despite unprecedented levels of care for the diabetic patient, diabetic retinopathy remains the major cause of blindness amongst the working population of the United Kingdom (2), and diabetic nephropathy a major cause of death in those patients who contract the disease in youth (3). These sobering statistics point to a lack of understanding of the pathogenesis of diabetic microangiopathy and a virtual absence of proven preventative therapy.
Keywords
- Capillary Pressure
- Continuous Subcutaneous Insulin Infusion
- Microvascular Blood Flow
- Poor Metabolic Control
- Diabetic Microangiopathy
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© 1987 Martinus Nijhoff Publishing, Boston
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Tooke, J.E. (1987). Clinical Investigation of the Diabetic Microcirculation. In: Tooke, J.E., Smaje, L.H. (eds) Clinical Investigation of the Microcirculation. Developments in Cardiovascular Medicine, vol 59. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2335-8_12
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DOI: https://doi.org/10.1007/978-1-4613-2335-8_12
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