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Modification of Cell Sensitivity to Anticancer Agents by Polyenes

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Biochemical Modulation of Anticancer Agents: Experimental and Clinical Approaches

Part of the book series: Developments in Oncology ((DION,volume 47))

Abstract

Unlike antimicrobial chemotherapy where a high degree of selective toxicity can be achieved, cancer chemotherapists are still searching for more selective drugs in order to obtain cures with minimal host toxicity. While antimicrobial chemotherapy has the advantage of a biological separation of target cells from host cells, specifically between prokaryotic and eukaryotic cells, respectively, or at worst between eukaryotes such as yeast and mammalian cells, unfortunately, in cancer chemotherapy, both the target and host cells are mammalian cells. Therefore, lacking cancer-specific agents to date, we are left with using mainly quantitative differences such as proliferative rate, metabolic pathways or specific enzyme characteristics. In biochemical modulation, one attempts to expand upon these differences. Since most of the current approaches to cancer chemotherapy are directed primarily at modifying the synthesis or function of DNA or RNA, consequently biochemical modulators have mainly been applied at these loci. However, other potential loci exist, one of which is the cell membrane.

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Authors
  1. Guy G. Chabot
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  2. Frederick A. Valeriote
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Editors and Affiliations

  1. Wayne State University School of Medicine, Detroit, Michigan, USA

    Frederick A. Valeriote  & Laurence H. Baker  & 

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© 1986 Martinus Nijhoff Publishing, Boston

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Chabot, G.G., Valeriote, F.A. (1986). Modification of Cell Sensitivity to Anticancer Agents by Polyenes. In: Valeriote, F.A., Baker, L.H. (eds) Biochemical Modulation of Anticancer Agents: Experimental and Clinical Approaches. Developments in Oncology, vol 47. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2331-0_14

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  • DOI: https://doi.org/10.1007/978-1-4613-2331-0_14

  • Publisher Name: Springer, Boston, MA

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