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Hematologic disorders associated with cancer: I. Red blood cell disorders

  • William M. Davis
Chapter
Part of the Cancer Treatment and Research book series (CTAR, volume 30)

Abstract

Anemia is the most common hematologic abnormality in patients with cancer. Anemia can be defined in several ways including: (1) decrease in red blood cell count, hemoglobin, or hematocrit (concentration measurements); (2) decrease in the red cell volume or Cr51 red cell mass. The mechanisms of cancer-related anemia are treated in detail in other reviews (1, 2).

Keywords

Chronic Lymphocytic Leukemia Hemolytic Anemia Iron Deficiency Anemia Polycythemia Vera Peripheral Blood Smear 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Bateman LJT, Beard MEJ. 1976. Malignant disease. In: Haematologic Aspects of Systemic Disease. Israel MCG, Delamore IW (eds). Saunders, London, pp 131–161.Google Scholar
  2. 2.
    Doll DC, Weiss RB. 1985. Neoplasia and the erythron. J Clin Oncol 3:429–446.PubMedGoogle Scholar
  3. 3.
    Eichner ER. 1979. Splenic function: Normal, too much and little. Am J Med 66:311–320.PubMedCrossRefGoogle Scholar
  4. 4.
    Goldman JM, Nolasco I. 1983. The spleen in myeloproliferative disorders. Clin Haematol 12:505–516.PubMedGoogle Scholar
  5. 5.
    Christinsen BE, Jonsson V, Videback A. 1983. The spleen in lymphoproliferative disorders. Clin Haematol 12:517–533.Google Scholar
  6. 6.
    Lynch EC, Alfrey CP Jr. 1965. Histiocytic medullary reticulosis. Hemolytic anemia due to erythrophagocytosis by histiocytes. Ann Intern Med 63:666–671.PubMedCrossRefGoogle Scholar
  7. 7.
    Jaffe ES, Costa I, Fauci AS et al. 1983. Malignant lymphoma and erythophagocytosis simulating malignant histiocytosis. Am J Med 75:741–749.PubMedCrossRefGoogle Scholar
  8. 8.
    Scott RB, Robb Smith AHT. 1939. Histiocytic medullary reticulosis. Lancet 2:194–198.CrossRefGoogle Scholar
  9. 9.
    Cartwright GE. 1966. The anemia of chronic disorders. Sem Hematol 3:351–373.Google Scholar
  10. 10.
    Cartweight GE, Lee GR. 1971. The anemia of chronic disease. Br J Haematol 21:147–152.CrossRefGoogle Scholar
  11. 11.
    Hyman GA, Gelhorn A, Harray J. 1956. Studies of the anemia of disseminated malignant neoplastic disease. II. Study of the life span of the erythrocyte. Blood 11:618–631.PubMedGoogle Scholar
  12. 12.
    Douglas SW, Adamson JW. 1975. The anemia of chronic disorders: Studies of marrow regulation and iron metabolism. Blood 45:55–65.PubMedGoogle Scholar
  13. 13.
    Dumick N, Kalkami V, Howard D et al. 1983. Mechanisms of abnormal erythropoiesis in malignancy. Cancer 51:1101–1106.CrossRefGoogle Scholar
  14. 14.
    Chanarin I. 1976. Investigation and management of megaloblastic anemia. Clin Haematol 5:747–763.Google Scholar
  15. 15.
    Krantz S. 1974. Pure red cell aplasia. N Engl J Med 291:345–350.PubMedCrossRefGoogle Scholar
  16. 16.
    Krantz, S. 1976. Diagnosis and treatment of pure red cell aplasia. Med Clin North Am 60:945–958.PubMedGoogle Scholar
  17. 17.
    Hirst E, Robertson TE. 1967. The syndrome of thymoma and erythroblastopenic anemia — A review of 56 cases. Medicine 46:225–264.PubMedCrossRefGoogle Scholar
  18. 18.
    Sieff C. 1983. Pure red cell aplasia. Br J Haematol 54:331–336.PubMedCrossRefGoogle Scholar
  19. 19.
    Mitchell ABS, Pinn G, Pegrum GD. 1971. Pure red cell aplasia and carcinoma. Blood 37:594–597.PubMedGoogle Scholar
  20. 20.
    Slater LM, Schultz MJ, Armentrout SA. 1974. Remission of pure red cell aplasia associated with non thymic malignancy. Cancer 44:1879–1881.CrossRefGoogle Scholar
  21. 21.
    Natelson EA, Lynch EC, Hettig RA, Alfrey CP. Jr. 1968. Histiocytic medullary reticulosis. Arch Intern Med 122:223–229.PubMedCrossRefGoogle Scholar
  22. 22.
    Tseng A Jr, Coleman CN, Cox RS et al. 1984. The treatment of malignant histiocytosis. Blood 64:48–53.PubMedGoogle Scholar
  23. 23.
    Dacie JV. 1975. Autoimmune haemolytic anemia. Arch Intern Med 135:1293–1306.PubMedCrossRefGoogle Scholar
  24. 24.
    Jones JE. 1973. Autoimmune disorders and malignant lymphoma. Cancer 31:1092–1098.PubMedCrossRefGoogle Scholar
  25. 25.
    Worlledge SH. 1978. The interpretation of a positive direct antiglobulin test. Br J Haematol 38:157–162.CrossRefGoogle Scholar
  26. 26.
    Sokol RJ, Hewitt S, Stamps BK. 1981. Autoimmune hemolytic anemia: An 18 year study of 865 cases referred to a regional transfusion center. Br Med J 282:2023–2027.CrossRefGoogle Scholar
  27. 27.
    Kyle RA, Kiely JM, Stickney JM. 1959. Acquired hemolytic anemia in chronic lymphocytic leukemia and the lymphomas. Arch Intern Med 104:61–67.CrossRefGoogle Scholar
  28. 28.
    Eisner E, Ley AB, Meyer K. 1967. Coombs-positive hemolytic anemia in Hodgkin’s disease. Ann Intern Med 66:258–273.PubMedCrossRefGoogle Scholar
  29. 29.
    Levine AM, Thornton P, Forman SJ et al. 1980. Positive Coombs test in Hodgkin’s disease: Significance and implications. Blood 55:607–611.PubMedGoogle Scholar
  30. 30.
    Garraty G, Petz LD, Wallerstein RO, Fudenberg HH. 1974. Autoimmune hemolytic anemia in Hodgkin’s disease associated with anti-It. Transfusion 14:226–231.CrossRefGoogle Scholar
  31. 31.
    Crisp D, Pruzanski W. 1982. B-cell neoplasms with homogenous cold-reacting antibodies (cold agglutinin). Am J Med 72:915–922.PubMedCrossRefGoogle Scholar
  32. 32.
    Pruzanski W, Shumak KH 1977. Biologic activity of cold reacting autoantibodies. N Engl J Med 297:578–592.CrossRefGoogle Scholar
  33. 33.
    Brain MC. 1970. Microangiopathic hemolytic anemia. Ann Rev Med 21:133–144.PubMedCrossRefGoogle Scholar
  34. 34.
    Lohrmann HP, Adam W, Heymer B, Kubanek A. 1973. Microangiopathic hemolytic anemia in metastatic carcinoma. Ann Intern Med 79:368–375.PubMedCrossRefGoogle Scholar
  35. 35.
    Brain MC. 1972. Microangiopathic hemolytic anemia. Br J Haematol 23:45–52.PubMedCrossRefGoogle Scholar
  36. 36.
    Antman KH, Skarin AT, Mayer RJ, Hargraves HK, Canellos GP. 1979. Microangiopathic hemolytic anemia and cancer: A review. Medicine 58:377–384.PubMedCrossRefGoogle Scholar
  37. 37.
    Alpert LI, Benisch B. 1970. Hemangioendothelioma of the liver associated with microangiopathic hemolytic anemia. Report of four cases. Am J Med 48:624–628.PubMedCrossRefGoogle Scholar
  38. 38.
    Davis S, Rambotti P, Grignoni F. 1985. Microangiopathic hemolytic anemia and pulmonary small cell carcinoma. Ann Intern Med 103:638.PubMedCrossRefGoogle Scholar
  39. 39.
    Cantrell JE, Phillips TM, Schein PS. 1985. Carcinoma-associated hemolytic anemia syndrome: A complication of Mitomycin C chemotherapy. J Clin Oncol 3:723–734.PubMedGoogle Scholar
  40. 40.
    Price TM, Murgo AJ, Keveney JJ et al. 1985. Renal failure and hemolytic anemia associated with Mitomycin C. A case report. Cancer 55:51–56.PubMedCrossRefGoogle Scholar
  41. 41.
    Clifford GO. 1966. The clinical significance of leucoerythroblastic anemia. Med Clin North Am 50:789–799.Google Scholar
  42. 42.
    Ehmen L. 1976. Bone marrow biopsy in the evaluation of lymphoma, carcinoma and granulomatous disorders. Am J Med 60:1–7.CrossRefGoogle Scholar
  43. 43.
    Valentine WN, Hennessey TC, Lang E et al. 1968. Polycythemia, erythrocytosis, and erythemia. Ann Intern Med 69:587–606.CrossRefGoogle Scholar
  44. 44.
    Daman A, Holub DA, Medicow MM et al. 1958. Polycythemia and renal carcinoma: Report of ten new cases, two with long standing hematologic remission following nephrectomy. Am J Med 25:182–197.CrossRefGoogle Scholar
  45. 45.
    Tso SC, Hua ASP. 1974. Erythrocytosis in hepatocellular carcinoma. Br J Haematol 28:497–503.PubMedCrossRefGoogle Scholar
  46. 46.
    Waldmann TA, Levin EH, Baldwin M. 1961. The association of polycythemia with a cerebellar hemangioblastoma. The production of an erythropoietin stimulating factor by the tumor. Am J Med 31:318–324.PubMedCrossRefGoogle Scholar
  47. 47.
    Lipsett MB, Odell WD, Rosenberg E, Waldmann TA. 1964. Numoral syndromes associated with nonendocrine tumors. Ann Intern Med 61:733.PubMedCrossRefGoogle Scholar
  48. 48.
    Adamson JW, Finch CA. 1968. Erythropoietin and the polycythemias. Ann. NY Acad Sci 149:560–568.PubMedCrossRefGoogle Scholar
  49. 49.
    Waldmann TA, Rosse WF, Swann RI. 1968. The erythropoietin-stimulating factors produced by tumors. Ann NY Acad Sci 149:509–515.PubMedCrossRefGoogle Scholar
  50. 50.
    Hammond A, Winnick A. 1974. Paraneoplastic erythrocytosis and ectopic erythropoietin. Ann NY Acad Sci 230:219–227.PubMedCrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff Publishers, Boston 1986

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  • William M. Davis

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