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Neuropeptides and their Possible Role as Auxiliary Messengers

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Neuroregulation of Autonomic, Endocrine and Immune Systems

Part of the book series: Topics in the Neurosciences ((TNSC,volume 2))

Abstract

The communication by Elliott published in 1905 [1] dealing with the action of adrenaline in peripheral tissues has often been considered to represent the first evidence that neurons communicate with effector cells in the periphery and with other neurons via chemical messengers [see book edited by Stjarne et al. (2)]. With regard to the chemical compounds involved in chemical transmission, focus has since then been on a fairly small number of compounds, including catecholamines such as dopamine, noradrenaline and adrenaline, as well as 5-hydroxytryptamine (5-HT), acetylcholine, and more recently a group of amino acids, for example glutamate and y-aminobutyric acid (GABA). More recent evidence suggests that also certain peptides may be present in neurons and may, in fact, be involved in the transmission processes at synapses [see 3 and 4], With the inclusion of peptides, the number of putative transmitters in the nervous system has increased dramatically [see 4].

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Authors and Affiliations

  1. 1Departments of Histology Physiological Chemistry and Pharmacology, Karolinska institutet, Stockholm, Sweden

    T. HÖkfelt, T. Melander, W. Staines, S. Wiesenfeld-Hallin, A. L. Hulting, S. Werner, P. Eneroth, J. A. Lindgren, B. Samuelsson, C. Patrono, A. Rökaeus, J. Fahrenkrug, S. A. Joseph & J. A. Fischer

  2. Department of Endocrinology and the Hormone Laboratory, Karolinska Hospital, Stockholm, Sweden

    T. Melander, W. Staines, S. Wiesenfeld-Hallin, A. L. Hulting, S. Werner, P. Eneroth, J. A. Lindgren, B. Samuelsson, C. Patrono, A. Rökaeus, J. Fahrenkrug, S. A. Joseph & J. A. Fischer

  3. Department of Clinical Neurophysiology, Huddinge Hospital, Stockholm, Sweden

    T. Melander, W. Staines, S. Wiesenfeld-Hallin, A. L. Hulting, S. Werner, P. Eneroth, J. A. Lindgren, B. Samuelsson, C. Patrono, A. Rökaeus, J. Fahrenkrug, S. A. Joseph & J. A. Fischer

  4. Department of Clinical Chemistry, Bispebjerg Hospital, Copenhagen, Denmark

    T. Melander, W. Staines, S. Wiesenfeld-Hallin, A. L. Hulting, S. Werner, P. Eneroth, J. A. Lindgren, B. Samuelsson, C. Patrono, A. Rökaeus, J. Fahrenkrug, S. A. Joseph & J. A. Fischer

  5. Neuroendocrine Unit, University of Rochester, Rochester, NY, USA

    T. Melander, W. Staines, S. Wiesenfeld-Hallin, A. L. Hulting, S. Werner, P. Eneroth, J. A. Lindgren, B. Samuelsson, C. Patrono, A. Rökaeus, J. Fahrenkrug, S. A. Joseph & J. A. Fischer

  6. Department of Pharmacology, Catholic University, Rome, Italy

    T. Melander, W. Staines, S. Wiesenfeld-Hallin, A. L. Hulting, S. Werner, P. Eneroth, J. A. Lindgren, B. Samuelsson, C. Patrono, A. Rökaeus, J. Fahrenkrug, S. A. Joseph & J. A. Fischer

  7. Departments of Orthopedic Surgery and Medicine, University of Zurich, Zurich, Switzerland

    T. Melander, W. Staines, S. Wiesenfeld-Hallin, A. L. Hulting, S. Werner, P. Eneroth, J. A. Lindgren, B. Samuelsson, C. Patrono, A. Rökaeus, J. Fahrenkrug, S. A. Joseph & J. A. Fischer

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  1. T. HÖkfelt
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Editors and Affiliations

  1. Monsanto Company, St. Louis, Missouri, USA

    Robert C. A. Frederickson Ph.D. (Senior Director) (Senior Director)

  2. Central Nervous System Research Searle Research and Development, G. D. Searle & Co., Skokie, Illinois, USA

    Robert C. A. Frederickson Ph.D. (Senior Director) (Senior Director)

  3. Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA, 46223

    Hugh C. Hendrie M. B. Ch.B. (Chairman and Albert E. Sterne Professor of Psychiatry) (Chairman and Albert E. Sterne Professor of Psychiatry)

  4. Section of Applied and Theoretical Neurobiology The Institute of Psychiatric Research and Departments of Psychiatry and Biochemistry, Indiana University School of Medicine Indiana University Medical Center, Indianapolis, Indiana, USA, 46223

    Joseph N. Hingtgen Ph.D. (Professor of Psychology and Neurobiology) (Professor of Psychology and Neurobiology)

  5. Departments of Pharmacology & Toxicology & Psgchiatry Program in Medical Neurobiologg, Indiana University School of Medicine, Indianapolis, Indiana, USA, 46223

    Morris H. Aprison Ph.D. (Distinguished Professor of Neurobiology and Biochemistry) (Distinguished Professor of Neurobiology and Biochemistry)

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© 1986 Matinus Nijhoff Publishing, Boston

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HÖkfelt, T. et al. (1986). Neuropeptides and their Possible Role as Auxiliary Messengers. In: Frederickson, R.C.A., Hendrie, H.C., Hingtgen, J.N., Aprison, M.H. (eds) Neuroregulation of Autonomic, Endocrine and Immune Systems. Topics in the Neurosciences, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2315-0_4

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  • DOI: https://doi.org/10.1007/978-1-4613-2315-0_4

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