Abstract
Metkephamid, a methionine-enkephalin analog, has a high affinity for the μ and δ, but not Κ, opioid receptor. Analgesic activity has been demonstrated in a number of preclinical analgesic tests (Frederickson et al, 1981; Hynes and Frederickson, 1982; Frederickson et al, 1983) and clinically (Bloomfield et al, 1982; Calimlim et al, 1982a; Calimlim et al, 1982b). Cross-tolerance and selective antagonism studies have differentiated metkephamid from morphine, and this suggest a role for the 6 opioid receptors in the analgesic effect of metkephamid (Hynes and Frederickson, 1982).
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© 1986 Matinus Nijhoff Publishing, Boston
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Hynes, M.D., Zimmerman, D.M., Gessellchen, P.D., Frederickson, R.C.A. (1986). THE OPIOID ANTAGONIST β-FUNALTREXAMINE (β -FNA) DIFFERENTIALLY ANTAGONIZES THE ANALGESIC ACTIVITY OF MORPHINE AND METKEPHAMID (LY127623), A METHIONINE-ENKEPHALIN ANALOG. In: Frederickson, R.C.A., Hendrie, H.C., Hingtgen, J.N., Aprison, M.H. (eds) Neuroregulation of Autonomic, Endocrine and Immune Systems. Topics in the Neurosciences, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2315-0_39
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DOI: https://doi.org/10.1007/978-1-4613-2315-0_39
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