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Neuroregulation of Autonomic, Endocrine and Immune Systems pp 509–513Cite as

Glucagon and Glucagon-Like Peptide Receptor Localization and Characterization in Rat Brain and Pituitary

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Part of the book series: Topics in the Neurosciences ((TNSC,volume 2))

Abstract

The peptide hormone glucagon, widely known for its activation of adenylate cyclase through its interaction with receptors on hepatocytes and other peripheral cells is coenco-ded on its genome with a leader sequence, glicentin-related peptide (GRPP), and two carboxyl terminal glucagon-like peptides (GLP-I and GLP-II) in mammals [1]. Anglerfish preproglu-cagon molecules appear to have a similar arrangement except for the lack of GLP-II• With growth hormone releasing factor (GRF), secretin, VIP, and PHI, glucagon and the glucagon-like peptides form a family of evolutionarily-related peptide hormones. Some cross-reaction between these hormones with their individual peripheral receptors is known. Immunoreactive glucagon (IRG) and glucagon-like immunoreactivity (GLI) have been immunohisto-chemically demonstrated in discrete areas of mammalian brains by several laboratories. Also, glucagon and glucagon-containing peptides have been identified in brain extracts [2].

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References

  1. Bell, G.I., Sanchez-Pescador, R., Layboun, P.J. and Najarian, R.C. (1983) Nature 304, 368 - 371.

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  2. Tager, H., Hohenboken, M., Markese, J. and Dinerstein, R.J. (1980) Proc. Natl. Acad. Sci. U.S.A. 77, 6229-6223.

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  4. England, R. D., Jenkins, W. T., Flanders, K. C. and Gurd, R. S. (1983) Biochemistry 22, 1722 - 1728.

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Author information

Authors and Affiliations

  1. Medical Sciences Program and Department of Chemistry, Indiana University, Bloomington, Indiana, 47405, USA

    Ruth S. Gurd & Naseema M. Hoosein

Authors
  1. Ruth S. Gurd
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  2. Naseema M. Hoosein
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Editor information

Editors and Affiliations

  1. Monsanto Company, St. Louis, Missouri, USA

    Robert C. A. Frederickson Ph.D. (Senior Director) (Senior Director)

  2. Central Nervous System Research Searle Research and Development, G. D. Searle & Co., Skokie, Illinois, USA

    Robert C. A. Frederickson Ph.D. (Senior Director) (Senior Director)

  3. Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA, 46223

    Hugh C. Hendrie M. B. Ch.B. (Chairman and Albert E. Sterne Professor of Psychiatry) (Chairman and Albert E. Sterne Professor of Psychiatry)

  4. Section of Applied and Theoretical Neurobiology The Institute of Psychiatric Research and Departments of Psychiatry and Biochemistry, Indiana University School of Medicine Indiana University Medical Center, Indianapolis, Indiana, USA, 46223

    Joseph N. Hingtgen Ph.D. (Professor of Psychology and Neurobiology) (Professor of Psychology and Neurobiology)

  5. Departments of Pharmacology & Toxicology & Psgchiatry Program in Medical Neurobiologg, Indiana University School of Medicine, Indianapolis, Indiana, USA, 46223

    Morris H. Aprison Ph.D. (Distinguished Professor of Neurobiology and Biochemistry) (Distinguished Professor of Neurobiology and Biochemistry)

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© 1986 Matinus Nijhoff Publishing, Boston

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Gurd, R.S., Hoosein, N.M. (1986). Glucagon and Glucagon-Like Peptide Receptor Localization and Characterization in Rat Brain and Pituitary. In: Frederickson, R.C.A., Hendrie, H.C., Hingtgen, J.N., Aprison, M.H. (eds) Neuroregulation of Autonomic, Endocrine and Immune Systems. Topics in the Neurosciences, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2315-0_30

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  • DOI: https://doi.org/10.1007/978-1-4613-2315-0_30

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9424-5

  • Online ISBN: 978-1-4613-2315-0

  • eBook Packages: Springer Book Archive

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