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Overview of Central Control Mechanisms and Disease Development

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Neuroregulation of Autonomic, Endocrine and Immune Systems

Part of the book series: Topics in the Neurosciences ((TNSC,volume 2))

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Abstract

A survey has been made of the conceptual changes that are taking place in our understanding of the pathogenesis and pathophysiology of selected diseases. Particular emphasis was placed on the role of the brain in pathogenesis. A part of our new understanding comes from the realization that symptoms and lesions cannot only be understood in local, anatomical terms, or changes in levels of this or that bodily constituent. Implicit in this statement is the belief that anatomical lesions follow and do not invariably antecede disturbances in function.

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References

  1. Prigogine, I. 1980. From Being to Becoming. San Francisco, W. H. Freeman.

    Google Scholar 

  2. Yen, S. S. C, Vela, P. and Rankin, J. 1970. Inappropriate secretion of follicle stimulating hormone and luteinizing hormone in polycystic ovarian disease. J. Clin. Endocrinol. Metab. 30, 435–442.

    Article  PubMed  CAS  Google Scholar 

  3. DeVane, G. W., Czekala, N. M., Judd, H. L. and Yen, S. S. C. 1975. Circulating gonadotropins, estrogens and androgens in polycystic ovary disease. Am. J. Obstet. Gynecol. 121, 496–500.

    PubMed  CAS  Google Scholar 

  4. Zumoff, B., Freeman, R., Coupey., S., Saenger, P., Markowitz, M. and Kream, J. 1983. A chronobiological abnormality in luteinizing hormone secretion in teenage girls with the polycystic ovary syndrome. N. Engl. J. Med. 309, 1206–1209.

    Article  PubMed  CAS  Google Scholar 

  5. Orr, W. C, Robinson, M. G. and Johnson, L. F. 1981. Acid clearance during sleep in the pathogenesis of reflux esophagitis. Dig. Dis. and Sci. 26, 423–427.

    Article  CAS  Google Scholar 

  6. Johnson, L. F. and DeMeester, T. R. 1974. Twenty-four hour pH monitoring of the distal esophagus, a quantitative measure of gastroesophageal reflux. Am. J. Gastroenterol. 62, 325–832.

    PubMed  CAS  Google Scholar 

  7. Orr, W. C. 1983. Studies of esophageal function during waking and sleep. In: Psychophysiology of the Gastrointestinal Tract. Edited by R. Hdlzl and W. E. Whitehead. New York: Plenum Press.

    Google Scholar 

  8. Dent, J., Dodds, W. J., Friedman, R. H., Sekiguchi, T., Hogan, W. J., Arndorfer, R. C. and Petrie, D. J. 1980. Mechanism of gastroesophageal reflux in recumbent asymptomatic human subjects. J. Clin. Invest. 65, 226–227.

    Article  Google Scholar 

  9. Moldofsky, H., Scarisbrick, P., England, R. and Smythe, H. 1975. Musculoskeletal symptoms and non REM sleep disturbances in patients with “fibrositis syndrome” and healthy subjects. Psychosom. Med. 37, 341–351.

    PubMed  CAS  Google Scholar 

  10. Moldofsky, H. and Scarisbrick, P. 1976. Induction of neurasthenic musculoskeletal pain syndrome by selective sleep stage deprivation. Psychosom. Med. 38, 35–44.

    PubMed  CAS  Google Scholar 

  11. Moldofsky, H., Tullis, C, Lue, F. A., Quance, G. and Davidson, J. 1984. Sleep-related myoclonus in rheumatic pain modulation disorder (fibrositis syndrome) and in excessive daytime somnolence. Psychosom. Med. 46. 145–151.

    Google Scholar 

  12. Rubenstein E. 1980. Diseases caused by impaired communication among cells. Sci. Amer. 242, 102–121.

    Article  PubMed  CAS  Google Scholar 

  13. Ishizaka, K. and Ishizaka, T. 1967. Identification of γE-antibodies as a carrier of reaginic activity. J. Immunol. 99, 1187–1198.

    Google Scholar 

  14. Ishizaka, K. and Ishizaka, T. 1970. Biological function of γE antibodies and mechanisms of reaginic hypersensitivity. Clin. Exp. Immunol. 6, 25–42.

    PubMed  CAS  Google Scholar 

  15. Johansson, S. G. O. 1967. Raised levels of a new immunoglobulin class (IgND) in asthma. Lancet 2, 951–953.

    Article  PubMed  CAS  Google Scholar 

  16. Berg, T. and Johansson, S. G. O. 1969. IgE concentrations in children with atopic disease. Int. Arch. Allergy Appl. Immunol. 36, 219–232.

    Article  PubMed  CAS  Google Scholar 

  17. Lichtenstein, L. M. 1977. Mediator release and asthma. In: Asthma... Physiology, Immunopharmacology, and Treatment. Edited by L. M. Lichtenstein and K. F. Austen. New York: Academic Press.

    Google Scholar 

  18. Austen, K. F. and Orange, R. P. 1975. Bronchial asthma: the possible role of chemical mediators of immediate hypersensitivity in the pathogenesis of subacute and chronic disease. Am. Rev. Respir. Dis. 112, 423–426.

    PubMed  CAS  Google Scholar 

  19. Gold, W. M. and Nadel, J. A. 1979. Advances in the understanding of asthma. West. J. Med. 130, 42–55.

    Google Scholar 

  20. Fillenz, M. and Widdicombe, J. G. 1972. Receptors of the lungs and airways. In: Handbook of Sensory Physiology. Edited by E. Neil. New York: Spnnger-Verlag.

    Google Scholar 

  21. Gold, W. M., Kessler, G. F. and Yu, D. Y. C. 1972. Role of the vagus nerves in experimental asthma in allergic dogs. J. Appl. Physiol. 33, 719–725.

    PubMed  CAS  Google Scholar 

  22. Yu, D. Y. C, Galant, S. P. and Gold, W. M. 1972. Inhibition of antigen-induced bronchoconstriction by atropine in asthmatic patients. J. Appl. Physiol. 32, 82–-828.

    PubMed  CAS  Google Scholar 

  23. Boushey, H. A. 1981. Neural mechanisms in asthma. In: Brain, Behavior,and Bodily Disease. Edited by H. Weiner, M. A. Hofer and A. J. Stunkard. New York: Raven Press.

    Google Scholar 

  24. Boyar, R. M., Katz, J. L., Finkelstein, J. W., Kapen, S., Weiner, H., Weitzman, E. D. and Hellman, L. 1974. Anorexia nervosa: immaturity of the 24-hour luteinizing hormone secretory pattern. N. Engl. J. Med. 291, 861865.

    Article  PubMed  CAS  Google Scholar 

  25. Pirke, K. M., Fichter, M. M., Lund, R. and Doerr, P. 1979. Twenty-four hour sleep-wake pattern of plasma LH in patients with anorexia nervosa. Acta Endocrinol. ( Kbh ) 92, 198–204.

    Google Scholar 

  26. Marshall, J. C. and Kelch, R. P. 1979. Low dose pulsatile gonadotropin releasing hormone in anorexia nervosa: a model of human pubertal development. J. Clin. Endocrinol. Metab. 49, 712–719.

    Article  PubMed  CAS  Google Scholar 

  27. Zumoff, B., Walsh, B. T., Katz, J. L., Levin, J., Rosenfeld, R. S., Kream, J. and Weiner, H. 1983. Subnormal plasma dehydroisoandrosterone to Cortisol ratio: a second hormonal parameter of autogenetic regression. J. Clin. Endocrinol. Metab. 56, 668–672.

    Article  PubMed  CAS  Google Scholar 

  28. Weiner, H. 1985. The physiology of eating disorders. Int. J. Eating Dis. In press.

    Google Scholar 

  29. Quigley, M. E., Sheehan, K. L., Casper, R. F. and Yen, S. S. C. 1980. Evidence for increased dopaminergic and opioid activity in patients with hypothalamic hypogonadotropic amenorrhea. J. Clin. Endocrinol. Metab. 50, 949–954.

    Article  PubMed  CAS  Google Scholar 

  30. Wakeling, A., DeSouza, V. F. A. and Beardwood, C. J. 1977. Effects of administered estrogen on luteinizing hormone release in subjects with anorexia nervosa in acute and recovery stages. In: Anorexia Nervosa. Edited by R. A. Vigersky. New York: Raven Press.

    Google Scholar 

  31. Wakeling, A., Marshall, J. C, Beardwood, C. J., DeSouza, V. F. A. and Russell, G. F. M. 1976. The effects of clomiphene citrate on the hypothalamic-pituitary-gonadal axis in anorexia nervosa. Psychol. Med. 6, 371–380.

    Article  PubMed  CAS  Google Scholar 

  32. Gold, P. W., Kaye, W., Robertson, G. L. and Ebert, M. H. 1983. Abnormalities in plasma and cerebrospinal anginine vasopressin in patients with anorexia nervosa. N. Engl. J. Med. 308, 1117–1123.

    Article  PubMed  CAS  Google Scholar 

  33. Hollenberg, N. K. and Adams, D. E. 1976. The renal circulation in hypertensive disease. Am. J. Med. 60, 773–784.

    CAS  Google Scholar 

  34. Weiner, H. 1981. Brain, behavior and bodily disease: a summary. In: Brain, Behavior and Bodily Disease. Edited by H. Weiner, M. A. Hofer and A. J. Stunkard. New York: Raven Press.

    Google Scholar 

  35. Hofer, M. A. 1984. Relationships as regulators: A psychobiological perspective on bereavement. Psychosom. Med. 46, 183–198.

    PubMed  CAS  Google Scholar 

  36. Weiner, H. 1985. The concept of ‘stress’ in the light of studies on disasters, unemployment and loss. In: Stress in Health and Disease. Edited by M. Zales. New York: Brunner/Mazel.

    Google Scholar 

  37. Henry, J. P., Meehan, J. P. and Stephens, P. M. 1967. The use of psychosocial stimuli to induce prolonged systolic hypertension in mice. Psychosom Med. 29, 408–432.

    PubMed  CAS  Google Scholar 

  38. Axelrod, J., Muller, R. A., Henry,.J. P. and Stephens, P. M. 1970. Changes in enzymes Involved in the biosynthesis and metabolism of noradrenaline and adrenaline after psychosocial stimulation. Nature (London) 225, 1059–1060.

    Article  CAS  Google Scholar 

  39. Morley, J. E. 1980. The neuroendocrine control of appetite: The role of the endogenous opiates, cholecystokinin, TRH, gamma-aminobutyric acid and the diazepam receptor. Life Sci. 27, 355–368.

    Article  PubMed  CAS  Google Scholar 

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© 1986 Matinus Nijhoff Publishing, Boston

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Weiner, H. (1986). Overview of Central Control Mechanisms and Disease Development. In: Frederickson, R.C.A., Hendrie, H.C., Hingtgen, J.N., Aprison, M.H. (eds) Neuroregulation of Autonomic, Endocrine and Immune Systems. Topics in the Neurosciences, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2315-0_19

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  • DOI: https://doi.org/10.1007/978-1-4613-2315-0_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9424-5

  • Online ISBN: 978-1-4613-2315-0

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