Abstract
Two responses of the immune system have relevance for those interested in artificial kidney performance: first, those associated with complement activation and the release of anaphylatoxins and, second, those associated with immune complex formation and the type-I hypersensitivity reaction. Kaplow and Goffinet in 1972 [1] noted that profound leukopenia occurs within 30 min after initiating cuprophan ® hemodialysis. This phenomenon is now known to be the result of sequestration of polymorphonuclear leukocytes in the pulmonary microvasculative rather than on the dialysis membrane. It was noted early on that not all membranes cause this phenomenon [2, 3]. Increased polymorph adhesiveness is produced when certain types of dialyzer membranes activate the complement system with release of the anaphylatoxin C5a which binds to specific polymorph receptors. The type-I hypersensitivity reaction was brought into focus by the practice of membrane reuse and is considered as the most likely mechanism underlying one form of first-use syndrome.
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© 1986 Martinus Nijhoff Publishing
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Henderson, L.W., Chenoweth, D.E. (1986). Immune Response to Reuse: Anaphylatoxins and IgE. In: Deane, N., Wineman, R.J., Bemis, J.A. (eds) Guide to Reprocessing of Hemodialyzers. Developments in Nephrology, vol 15. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2313-6_10
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DOI: https://doi.org/10.1007/978-1-4613-2313-6_10
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