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Breast Cancer: Origins, Detection, and Treatment pp 97–111Cite as

New Approaches to the Pathology of Breast Cancer; Can Immunohistochemistry Add New Information?

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Part of the book series: Developments in Oncology ((DION,volume 43))

Abstract

If we want to evaluate the contribution of immunohistochemistry to the understanding of breast disease, we must first consider the role of histopathology. The aims of histopathological studies are:

  1. 1.

    differentiation between benign and malignant lesions.

  2. 2.

    classification and grading of malignancy (relevant for prognosis).

  3. 3.

    staging and extent of disease (relevant for prognosis).

  4. 4.

    in case of metastasis of occult primary tumor: differential diagnosis of possible primary tumor.

  5. 4.

    giving insight in histogenesis and tumor biology.

Especially in the last decade a large number of polyclonal and monoclonal antibodies and fluorescein- or enzymeconjugated lectins has been developed to define more precisely the composition and functional characteristics of the mammary gland. Some recent developments which may contribute to histopathological studies will be reviewed, without the pretention to be complete. Emphasis will be given to markers that can be applied to routinely fixed, paraffin-embedded material.

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References

  1. Naritoku, W.U. and Taylor, C.R. J. Histochem. Cytochem. 30: 253–260, 1982.

    Article  PubMed  CAS  Google Scholar 

  2. De Jong, A.S.H., Van Kessel-van Vark, M. and Raap, A.K. Histochem. J. (submitted for publication).

    Google Scholar 

  3. Heyderman, E. J. Clin. Pathol. 312: 971–978, 1979.

    Article  Google Scholar 

  4. Erlandson, R.A. Am. J. Surg. Path 8: 615–624, 1984.

    Article  Google Scholar 

  5. Von Kleist, S. In: Carcinoembryonic proteins, Vol. 1 (Ed. F.G. Lehman), Elsevier, pp. 35–39, 1979.

    Google Scholar 

  6. Walker, R.A. J. Cliru Pathol. 33: 356–360, 1980.

    Article  CAS  Google Scholar 

  7. Nap, M., Ter Moor, K.A. and Fleuren, G.J. Am. J. Clin. Pathol. 79: 25–31, 1983.

    PubMed  CAS  Google Scholar 

  8. Bussolati, G., Gugliotta,P. and Papotti, M. In: New Frontiers in mamma pathology, Vol. 2 (Eds. K.M. Hollmann, J.M. Verlev), Plenum Press, New York, pp. 249–264, 1983.

    Google Scholar 

  9. Taylor-Papadimitriou, J., Burchell, J. Lancet i: 458–459, 1985.

    Article  Google Scholar 

  10. Foster, C.S. and Neville, A.M. Human Pathol. 5: 502–513, 1984.

    Article  Google Scholar 

  11. Altmannsberger, M., Osborn, M., Hölscher, A., Schauer, A. and Weber, K. Virchows Arch. B (Cell Pathol.)37: 277–284, 1981.

    Article  CAS  Google Scholar 

  12. Springer, G.F., Desai, P.R. and Banatwala, I. J. Natl. Cancer Inst. 54: 335–339. 1975.

    PubMed  CAS  Google Scholar 

  13. Gusterson, B.A., Warburton, M.J., Monaghan, T., Foster, C., Edwards, P., Kraft, N., Smith, C., Mitchell, D., Rudland, P.S., Neville, A.M. and Hancock, W. Behring Inst. Mitt. 74: 39–48, 1984.

    PubMed  Google Scholar 

  14. King, W.J., Greene, G.L. Nature 307: 745–747, 1984.

    Article  PubMed  CAS  Google Scholar 

  15. King, W.J., De Sombre, E.R., Jensen, E.V. and Greene, G.L. Cancer Res. 45: 293–304, 1985.

    PubMed  CAS  Google Scholar 

  16. Skovgaard Poulsen, H., Ozzello, L., King, W.J. and Greene, G.L. J. Histochem. Cytochem. 33: 87–92 1985.

    Article  Google Scholar 

  17. Cross, A.S., Azzopardi, J.G., Krausz, T., Van Noorden, S. and Polak, J.M. Histopathology 9: 21–37 1985.

    PubMed  CAS  Google Scholar 

  18. Ceriani, R.L., Thompson, K., Peterson, J.A. and Abraham, S. Proc. Natl. Acad. Sci. 74: 582–586, 1977.

    Article  PubMed  CAS  Google Scholar 

  19. Ceriani, R.L., Peterson, J.A., Lee, J.Y., Moncada, R. and Blank, E.W. Somat. Cell Genet. 9: 415–427, 1983.

    Article  PubMed  CAS  Google Scholar 

  20. Heyderman, E., Steele, K. and Ormerod, M.G. J. Clin. Pathol. 32: 35–39, 1979.

    Article  PubMed  CAS  Google Scholar 

  21. Sloane, J.P. and Ormerod, M.G. Cancer 47: 1786–1795, 1981.

    Article  PubMed  CAS  Google Scholar 

  22. Ormerod, M.G., Steele, K., Westwood, J.H. and Mazzini, M.N. Br. J. Cancer 48: 533–541, 1983.

    Article  PubMed  CAS  Google Scholar 

  23. Arklie,T., Taylor-Papadimitriou, J., Bodmer W., Egan, M. and Millis, R. Int. J. Cancer 28: 23–30, 1981.

    Article  PubMed  CAS  Google Scholar 

  24. Taylor-Papadimitriou, J., Peterson, J.A., Arklie, J., Burchell, J. Ceriani, R.L. and Bodmer, W.F. Int. J. Cancer 28: 17–21, 1981.

    Article  PubMed  CAS  Google Scholar 

  25. Hilkens, J., Buys, F., Hilgers, J., Hageman, Ph., Calafat, J. Sonnenberg, A. and van der Valk, M. Int. J. Cancer 34: 197–206, 1984.

    Article  Google Scholar 

  26. Foster, C.S., Edwards, P.A.W., Dinsdale,E.A. and Neville, A.M. Virchows Archiv A 394: 279–293, 1982.

    CAS  Google Scholar 

  27. Foster, C.S., Dinsdale, E.A., Edwards, P.A.W. and Neville, A.M. Virchows Archiv A 394: 295–305, 1982.

    CAS  Google Scholar 

  28. Imam A., Taylor, CR and Tökes, Z.A. Cancer Res. 44: 2016–2022, 1984.

    PubMed  CAS  Google Scholar 

  29. Klein, P.J., Vierbuchen, M., Schulz, K.D., Farrar, G., Fischer, J. Uhlenbruck G. and Fischer, R. Cancer Det. Prev. 6: 199–206, 1983.

    CAS  Google Scholar 

  30. Mènard, S., Tagliabue, E., Canevari, S., Fossati, G. and Colnaghi,M.I. Cancer Res. 43: 1295–1300, 1983.

    PubMed  Google Scholar 

  31. Canevari, S., Fossati, G., Balsari, A., Sonnino, S. and Colnaghi, M.I. Cancer Res. 43: 1301–1305, 1983.

    PubMed  CAS  Google Scholar 

  32. Mariani-Costantini, R., Colnaghi, M.I., Leoni, F., Menard, S., Cerasoli, S. and Rilke, F. Virchows Arch. (Pathol. Anat.) 402: 389–404, 1984.

    Article  CAS  Google Scholar 

  33. Yuan, D., Hendler, F.J. and Vitetta, E.S. J. Natl. Cancer Inst. 68: 719–728, 1982.

    PubMed  CAS  Google Scholar 

  34. Hendler, F.J. and Yuan, D. Cancer Res. 45: 421–429, 1985.

    PubMed  CAS  Google Scholar 

  35. Papsidero, L.D., Croghan, G.A., O’Connel, M.J., Valenzueala, L.D. Nernoto, T. and Ming Chu, T. Cancer Res. 43: 1741–1747, 1983.

    PubMed  CAS  Google Scholar 

  36. Croahan, G.A., Papsidero, L.D., Valenzueala, L.A., Nernoto, T., Penetrante, R. and Ming Chu, T. Cancer Res. 43: 4980–4988, 1983.

    Google Scholar 

  37. Thompson, C.H., Jones, S.L., Whitehead, R.M. and Mckenzie, I.F.C. J. Natl. Cancer Inst. 70: 409–420, 1983.

    CAS  Google Scholar 

  38. Colcher, D., Hand, P.H77 Nuti, M. and Schlom, J. Proc. Natl. Acad. Sci. 78: 3199–3203, 1981.

    Article  PubMed  CAS  Google Scholar 

  39. Nuti,IT., Teramoto, Y.A., Mariani-Costantini, R., Horan Hand, P., Colcher, D., Schlom, J. Int. J. Cancer 29: 539–545, 1982.

    Article  PubMed  CAS  Google Scholar 

  40. Ellis, I.O., Robbins, R.A., Eiston, C.W., Blarney, R.W., Ferry, B. and Baldwin, R.W. Histopathology 8: 501–516, 1984.

    Article  PubMed  CAS  Google Scholar 

  41. Kufe, D., Inghirami, G., Abe, M., Hayes, A., Justi-Wheeler, H. and Schlom, J. Hybridoma 3: 223–232, 1984.

    Article  PubMed  CAS  Google Scholar 

  42. Schlom, J., Wunderlich, D. and Teramoto, Y.A. Proc. Natl. Acad. Sci. 77: 6841–6845, 1980.

    Google Scholar 

  43. Teramoto, Y.A., Mariani, R., Wunderlich, D., Schlom, J. Cancer 50: 2411249, 1982.

    Article  Google Scholar 

  44. Imam A., Drushella, M.M., Taylor, C.R. and Tökes, Z.A. Cancer Res. 45: 263–271, 1985.

    PubMed  CAS  Google Scholar 

  45. Yu, G.S.M., Kadish, A.S., Johnson, A.B., Marcus, D.M. Am. J. Clin. Path. 74: 453–457, 1980.

    PubMed  CAS  Google Scholar 

  46. Leung, P., Plow, E.F., Nakamura, R.M. and Edgington, T. S. J. Immunol. 121: 1287–1296, 1978.

    PubMed  CAS  Google Scholar 

  47. Leung, J.P. Edgington, T.S. Cancer Res. 40: 662–666, 1980.

    PubMed  CAS  Google Scholar 

  48. Edwards, P.A. and Brooks, I.M. J. Histochem. Cytochem. 32: 531–537, 1984.

    Article  CAS  Google Scholar 

  49. Edwards, P.A.W. Br. J. Cancer 51: 149–160, 1985.

    Article  PubMed  CAS  Google Scholar 

  50. Feizi, T. Nature 314: 53–57, 1985.

    Article  PubMed  CAS  Google Scholar 

  51. Walker, R.A. J. Pathol. 142: 279–291, 1984.

    Article  PubMed  CAS  Google Scholar 

  52. Walker, R.A. J. Pathol. 144: 101–108, 1984.

    Article  PubMed  CAS  Google Scholar 

  53. Peterson, J.A., Ceriani, R.L., Blank, E.W. and Osvaldo, L. Cancer Res 43: 4291–4296, 1983.

    PubMed  CAS  Google Scholar 

  54. Ceriani, R.L., Peterson, J.A. and Blank, E.W. Cancer Res. 44: 3033–3039, 1984.

    PubMed  CAS  Google Scholar 

  55. Ashall, F., Bramwell, M.E. and Harris, H. Lancet ii, 1–6, 1982.

    Article  Google Scholar 

  56. Simpson, H.W., Candlish, W., Liddle, C., McGregor, M., Mutch, F. and Tinkler, B. Histopathology 8: 481–499, 1984.

    Article  Google Scholar 

  57. Springer, G.F., Desai, P.R., Murthy, M.S., Yang, H.J. and Scanion, E.F. Transfusion 19: 233–249, 1979.

    Article  Google Scholar 

  58. Howard, D.R. and Taylor, C.R. Cancer Res. 43: 2279–2287, 1979.

    CAS  Google Scholar 

  59. Klein, P.J., Newman, R.A., Müller, P., Uhlenbruck, G., Citoler, P., Schäfer, H.E., Lennartz, K.J. and Fischer, R.F. J. Cancer Res. Clin. Oncol. 93: 205–214, 1979.

    Article  CAS  Google Scholar 

  60. Stegner, H.E., Fischer, K. and Poschmann, A. Tumor Diagnostik 3: 127–130, 1981.

    Google Scholar 

  61. Hageman, Ph., Bobrow, L., Van der Valk, M.A., Misdorp, W., and Hilkens, J. In: The lectins, Vol. 3 (Eds. T.C. Bø-Hanssen, G.A. Spengler) W. de Gruyter, Berlin, pp. 105–118, 1983.

    Google Scholar 

  62. Franklin, W.A. Cancer 51: 295–300, 1983.

    Article  PubMed  CAS  Google Scholar 

  63. Howard, D.R., Ferguson, P. and Batsakis, J.G. Cancer 47: 2872–2877, 1981.

    Article  PubMed  CAS  Google Scholar 

  64. Newman, R.A., Klein, P.J. and Rudland, P.S. J. Natl. Cancer Inst. 63: 1339–1346, 1979.

    Google Scholar 

  65. Klein, P.J., Vierbuchen,M., Wurtz, H., Schulz, K.D. and Newman, R.A. Br.J.Cancer 44: 746–748, 1981

    Article  PubMed  CAS  Google Scholar 

  66. Springer, G.F., Taylor, C.R., Howard, D.R., Tegtmeyer,H., Desai,P.R., Murthy, S.M., Felder, B. and Scanion, E.F. Cancer 55: 561–569, 1985.

    Article  PubMed  CAS  Google Scholar 

  67. Papotti, M., Gugliotta, P., Eusebi, V. and Bussolati,G. Am.J.Surg. Pathol. 7: 457–461, 1983.

    Article  Google Scholar 

  68. Nap, M., Keuning, H., Burtin, P.,Oosterhuis, J.W. and Fleuren, G.J. Am.J.Clin.Pathol. 82: 526–534, 1984.

    PubMed  CAS  Google Scholar 

  69. Bussolati, G., Botla, G. and Gugliotta, P. Virchows Archiv B 34: 251–259, 1980.

    Article  CAS  Google Scholar 

  70. Gusterson, B.A., Warburton, M.J., Mitchell, D., Ellison, M.L., Neville, A.M., Rudland, P.S. Cancer Res. 42: 4763–4770, 1982.

    PubMed  CAS  Google Scholar 

  71. Papotti, M., Gugliotta, P., Ghiringhello, ET and Bussolati, G. Histopathology 8: 963–975, 1984.

    Article  PubMed  CAS  Google Scholar 

  72. Azzopardi, J.G. Problems in breast pathology. W.B.Saunders, London, 1979

    Google Scholar 

  73. Shousha, S. and Lyssiotis, T. Histopathology 2: 433–447, 1978.

    Article  PubMed  CAS  Google Scholar 

  74. Shousha, S., Lyssiotis, T., Godfrey, V.M. and Scheuer, P.J. Br.Med. J. 1: 777–779, 1979.

    Article  PubMed  CAS  Google Scholar 

  75. Rolt Smith, S., Howell, A., Minawa, A. and Morrison, J.M. Br. J. Cancer 46: 757–764, 1982.

    Article  Google Scholar 

  76. Wilkinson, M.J.S., Howell, A., Harris, M., Taylor-Papadimitriou, J., Swindell, R., and Sellwood, R.A. Int.J.Cancer 33: 299–304, 1984.

    Article  PubMed  CAS  Google Scholar 

  77. Berry, N., Jones, D.B., Smallwood, J., Taylor, I, Kirkham, N., Taylor-Papadimitriou, J. Br.J.Cancer 51; 179–186, 1985.

    Article  PubMed  CAS  Google Scholar 

  78. Horne, C.W., Reid, I.N. and Milne, G.D. Lancet ii: 279–282, 1976.

    Article  Google Scholar 

  79. Kuhajda, F.P., Bohn, H. and Mendelsohn, G. Cancer 54: 1392–1396, 1984.

    Article  PubMed  CAS  Google Scholar 

  80. Barry, J.D., Koch, T.J., Cohen, C., Brigati, D.J. and Sharkey, F.E. Am.J.Clin.Pathol. 82: 582–585, 1984.

    PubMed  CAS  Google Scholar 

  81. Keydar, I., Selzer, G., Chaitili, S., Hareuveni, M., Karbi, S. and Hizi, A Eur.J.Cancer Clin.Oncol. 18: 1321–1328, 1982.

    Article  PubMed  CAS  Google Scholar 

  82. Mesa-Tejada, R., Keydar, I., Ramanarayanan, M., Ohno, T., Fenoglio, C. and Spiegelman, S. AACR Proc. 20: 276, 1979.

    Google Scholar 

  83. Levine, P.H., Mesa-Tejada, RT, Keydar, I. and Tabbane, F. Int.J. Cancer 33: 305–308, 1984. 0

    Google Scholar 

  84. Mesa-Tejada, R., Keydar, I., Ramanarayanan, M., Ohno, T., Fenoglio, C. and Spiegelman, S. Proc.Natl. Acad. Sei. 75: 1529–1533, 1978.

    Article  PubMed  CAS  Google Scholar 

  85. Heyderman, E. and Macartney, J.C. Lancet i: 109, 1985.

    Article  Google Scholar 

  86. Gatter, K.C. and Mason, D.Y. Seminars in Oncology 9: 517–525, 1982.

    PubMed  CAS  Google Scholar 

  87. Henzen-Logmans, S.C., Mullink, H., Vennegoor, C., Hilgers, J. and Meyer, C.J.L.M. Am.J.Clin.Pathol. submitted for publication.

    Google Scholar 

  88. Sloane, J.P., Ormerod, M.G., Imrie, S. and Coombes, R.C. Br.J.Cancer 42: 392–398, 1980.

    Google Scholar 

  89. Dearnaley, D.P., Sloane, J.P., Ormerod, M.G., Steele, K., Coombes, R.C., Clink, H., Powl es, T.J., Ford, H.T., Gazet, J.C. and Neville, A.M. Br.J.Cancer 44: 85–90, 1981.

    Article  PubMed  CAS  Google Scholar 

  90. Gugliotta, P., Botta, G. and Bussolati, G. Histochem.J.13: 953–959, 1981.

    Article  PubMed  CAS  Google Scholar 

  91. Wells, C.A., Heryet, A., Brochier, J., Gatter, K.C. and Mäson, D.Y. Br.J.Cancer 50: 193–197, 1984.

    Article  PubMed  CAS  Google Scholar 

  92. Redding, W.H, Monaghan, P., Imrie, S.F., Ormerod, M.G., Gazet, J.C., Coombes, R.C., Clink, H.M., Dearnaly, D.P., Sloane, J.P., Powles, T.J. and Neville, A.M. Lancet ii: 1271–1274, 1983.

    Article  Google Scholar 

  93. Delsol, G., Gatter, K.C., Stein, H., Erber, W.N., Pulford, K.A.F., Zinne, K. and Mason, D.V. Lancet ii: 1124–1129, 1984.

    Article  Google Scholar 

  94. Sloane, J.P., Dearnaley, D.P. and ürmerod, M.G. Lancet i: 109–110, 1985.

    Article  PubMed  CAS  Google Scholar 

  95. Clayton, F., Nelson, G.0. and Hanssen, G.M. Arch.Pathol.106: 268.–270,1982

    Article  PubMed  CAS  Google Scholar 

  96. Lee, A.K., Delellis, R.A. and Rosen, R0P. Am.J0Surg.Pathol 8: 93–100, 1984

    Article  PubMed  CAS  Google Scholar 

  97. Huszar, M., Herczeg, E., Lieberman, Y. and Geiger, B. Hum.Pathol. 15: 532–538, 1984

    Google Scholar 

  98. Horan-Hand, P., Thor, A., Wunderlich, D., Muraro, R., Caruso, A. and Schlom, J. Proc.Natl. Acad.Sci. 81: 5227–5231, 1984.

    Article  Google Scholar 

  99. Kraus, M.H., Yuasa, Y. and Aaronson, S.A. Proc.Natl.Acad.Sci. 81: 5348–5388, 1984.

    Article  Google Scholar 

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Authors and Affiliations

  1. Division of Clinical Oncology and Department of Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands

    PH. Hageman & J. L. Peterse

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  1. PH. Hageman
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  1. AMC Cancer Research Center, Denver, Colorado, USA

    Marvin A. Rich  & Jean Carol Hager  & 

  2. Imperial Cancer Research Fund, London, UK

    Joyce Taylor-Papadimitriou

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Hageman, P., Peterse, J.L. (1986). New Approaches to the Pathology of Breast Cancer; Can Immunohistochemistry Add New Information?. In: Rich, M.A., Hager, J.C., Taylor-Papadimitriou, J. (eds) Breast Cancer: Origins, Detection, and Treatment. Developments in Oncology, vol 43. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2309-9_9

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