New Approaches to the Pathology of Breast Cancer; Can Immunohistochemistry Add New Information?

  • PH. Hageman
  • J. L. Peterse
Part of the Developments in Oncology book series (DION, volume 43)

Abstract

If we want to evaluate the contribution of immunohistochemistry to the understanding of breast disease, we must first consider the role of histopathology. The aims of histopathological studies are:
  1. 1.

    differentiation between benign and malignant lesions.

     
  2. 2.

    classification and grading of malignancy (relevant for prognosis).

     
  3. 3.

    staging and extent of disease (relevant for prognosis).

     
  4. 4.

    in case of metastasis of occult primary tumor: differential diagnosis of possible primary tumor.

     
  5. 4.

    giving insight in histogenesis and tumor biology.

     
Especially in the last decade a large number of polyclonal and monoclonal antibodies and fluorescein- or enzymeconjugated lectins has been developed to define more precisely the composition and functional characteristics of the mammary gland. Some recent developments which may contribute to histopathological studies will be reviewed, without the pretention to be complete. Emphasis will be given to markers that can be applied to routinely fixed, paraffin-embedded material.

Keywords

Sugar Carbohydrate Lymphoma Estrogen Adenocarcinoma 

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Copyright information

© Martinus Nijhoff Publishing, Boston 1986

Authors and Affiliations

  • PH. Hageman
    • 1
  • J. L. Peterse
    • 1
  1. 1.Division of Clinical Oncology and Department of PathologyNetherlands Cancer InstituteAmsterdamThe Netherlands

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