Abstract
We are interested in defining genes implicated in the development of mammary tumors. In mice, mammary tumors can be induced by a variety of methods, including hormones, chemical carcinogens, gene transfer into germ line and a retrovirus (1.2).A direct view on specific genetic alterations in mammary tumorigenesis is nevertheless not always obtained. The identification of oncogenes specific for mammary tumors could eventually be helpful in, for example, examining what the mechanism of action of hormonal carcinogenesis is. The large majority of the cellular oncogenes has been discovered with the aid of retroviruses (3, 4); thus, the Mouse Mammary Tumor Virus (MMTV) could be the system of choice to define mammary oncogenes.
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© 1986 Martinus Nijhoff Publishing, Boston
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Nusse, R., Van Ooyen, A., Schuuring, E., Van Lohuizen, M., Rijsewijk, F. (1986). Structural and Biological Properties of the INT-1 Mammary Oncogene. In: Rich, M.A., Hager, J.C., Taylor-Papadimitriou, J. (eds) Breast Cancer: Origins, Detection, and Treatment. Developments in Oncology, vol 43. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2309-9_13
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DOI: https://doi.org/10.1007/978-1-4613-2309-9_13
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