Abstract
If we are to understand cancer, we must understand its origins and its evolution. The current concept, that cancer results from somatic cell mutation, means that the molecular origin and evolution of the disease must also be understood. At present, most of our information about the molecular biology of neoplastic progression comes from either lymphoid cells or fibroblasts in tissue culture (1–3). Unfortunately, breast cancer is a solid tumor of epithelial origin. In fact, most cancers develop in solid organs and, with rare exception, we know very little about the origin and evolution of such neoplasms.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Novell, P.C. Science. 194: 23–28, 1976.
Land, H., Parada, L.F., and Weinberg. Nature. 304: 596–602, 1983.
Cooper, G.H. Science. 218: 801–806, 1982.
Fanning, T.G., and Cardiff, R.D. Adv. in Viral Onco. 4: 71–94, 1984.
Cardiff, R.D., Adv. in Cancer Res. 42:167–190, 1984.
Nandi, S., and McGrath, C.M., Adv. Cancer Res. 17: 353–414, 1973.
Varmus, H.E., and Swanstrom, R. In: RNA Tumor Viruses, edited by R. Weiss, N. Leich, H.E. Varmus, and J. Coffin, pp 369–512, Cold Spring Harbor Lab., N.Y.
Cohen, J.C., Shank, P.R., Morris, V.L., Cardiff, R.D., and Varmus, H.E., Cell. 16: 333–345, 1979.
Varmus, H.E., Science. 216: 812–820, 1982.
Varmus, H.E., Cancer Surveys. 1: 309–319, 1982.
Cardiff, R.D., Wellings, S.R., and Faulkin, L.J., Cancer. 39: 2734–2746, 1977.
Medina, D., Methods Cancer Res. 7: 3–53, 1973.
Cardiff, R.D., Morris, D.W., and Young, L.J.T., J. Natl. Cancer Inst. 71: 1011–1019, 1983.
Cardiff, R.D., Fanning, T.G., Morris, D.W., Ashley, R.L., and Faulkin, L.J., Cancer Res. 41: 3024–3029, 1981.
Nusse, R., and Varmus, H.E., Cell. 31: 99–109, 1982.
Peters, G., Brookes, S., Smith, R., and Dickson C., Cell. 33: 369–377, 1983.
Fanning, T.G., Vassos, A., and Cardiff, R.D., J. Virol. 41: 1007–1013, 1982.
Heppner, G.H., Shapiro, W.R., and Rankin, J.K., Pediatr. Oncol. 1: 99–116, 1981.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Martinus Nijhoff Publishing, Boston
About this chapter
Cite this chapter
Cardiff, R.D., Morris, D.W., Young, L.J.T., Strange, R. (1986). MuMTV Genotype, Protoneoplasia, and Tumor Progression. In: Rich, M.A., Hager, J.C., Taylor-Papadimitriou, J. (eds) Breast Cancer: Origins, Detection, and Treatment. Developments in Oncology, vol 43. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2309-9_12
Download citation
DOI: https://doi.org/10.1007/978-1-4613-2309-9_12
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9421-4
Online ISBN: 978-1-4613-2309-9
eBook Packages: Springer Book Archive