Abstract
The action of peptides on neuromuscular transmission is of a potential interest from two different viewpoints. First, under physiological conditions peptides may serve as potential modulators of synaptic transmission. For example, it has been shown that, the vasoactive intestinal peptide (VIP), has augmenting effect on the number of neurotransmitter quanta released by nerve stimulation (Gold, 1982) The adrenocorticotropic hormone (ACTH) also increases transmitter release, but unlike VIP, it has a long-lasting enhancing action (Johnston et al, 1983). Peptides differ not only in the duration of their action, but also in the characteristics of their effect. The 11 amino acid peptide, Substance P has a biphasic effect on transmitter release, (Steinackre, 1977), while enkephalin reduces the quantal content of release at the frog neuromuscular junction (Bixby and Spitzer, 1983).
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Eertagna, X.Y., Nicholson, W.E., Pettengill, O.S., Sorenson, G.D., Fount, C.D. and Orth, D.N. (1978). Ectoplc production of high molecular weight calcitonin and corticotropin by human small-cell carcinoma cells in tissue culture: Evidence for separate precursors. J. Clin. Endocrinol. Metabol. 47: 1390–1393.
Bertagna, X.Y., Nicholson, W.E., Sorenson, G.D., Pettengill, O.S., Mount, CD. and Orth, D.N. (1978). Corticotropin, lipotropin and-endorphin production by a human nonpituitary tumour in culture: Evidence for a common precursor. Proc. Natl. Acad. Sci. USA 75.: 5160–5164.
Bixby, J.L. and Spitzer, N.C. (1983). Enkephalin reduces quantal content at the frog neuromuscular junction. Nature, 301: 431–432.
Brinck-Johnsen, T., Pettengill, O.S., Brinck-Johnsen, K., Sorenson, G.D. and Maurer, L.H. (1979). Estrogen production by an established cell line from pulmonary small-cell anaplastic carcinoma. J. Steroid. Eiochem. 10: 339–340.
Eaton, L.N. and Lambert, E.H. (1957). Electromyography and electric stimulation of nerves in diseases of motor unit. Am. J. Physiol. 163: 1117–1124.
Ellison, M., Woodhouse, D., Hillyard, C, Dowsett, M., Coombes, R.S., Gilby, E.D., Greenberg, P.B. and Neville, A.M. (1975). Immunoreactive calcitonin production by human lung carcinoma cells in culture. Br. J. Cancer 32: 373–379.
Gazdar, A.F., Carney, D.N., Russell, E.K., Sims, H.L., Baylin, S.B., Bunn, P.A., Guccion, J.G. and Minna, J.D. (1980). Establishment of continuous clonable cultures of small-cell carcinoma of the lung which have amine precursor uptake and decarboxylation cell properties. Cancer Res. 40: 3502–3507.
Gold, N.R., (1982). The effect of Vasoactive Intestinal Peptides on neuromuscular transmission in the frog. J. Physiol. 327: 325–335.
Henson, R.A. (1974). Neuromuscular disorders associated with malignant disease. In: Disorders of Voluntary Muscle. J.N. Walton. Ed., Churchill-Livingstone, pp.766–769.
Johnston, M.F., Kravitz, E.A., Neiri, H. and Rahamimoff, R. (1983). ACTH causes long-lasting potentiation of transmitter release from frog motor nerve terminals. Science 222: 1071–1072.
Lambert, E.H. and Elmqvist, D. (1971). Ouantal components of endplate potentials in myasthenic syndrome. Ann. N.Y. Acad. Sci. 183: 183–199.
Lambert, E.H., Rooke, E.D., Eaton, L.M. and Hodgson, C.H. (1961). Myasthenie syndrome occassionally associated with bronchial neoplasm: Neurophyisological studies. In: Nyasthenia Gravis, H.R. Viets (Ed.) 2nd International Symposium Proceedings. Springfield, I11., Charles C. Thomas, Publisher, pp.362–410.
Moody, T.W., Pert, C.B., Gazdar, A.F., Carney, D.N. and Minna, J.D. (1981). High levels of intracellular bombesin characterize human small-cell lung carcinoma. Science 214: 1246–1248.
Olgiati, V.R., Guidobono, F., Netti, C. and Pecile, A. (1983). Localization of calcitonin binding sites in rat central nervous system: evidence of its neuroactivity. Brain Res. 265: 209–215.
Pettengill, O.S., Faulkner, C.S., Wurster-Hill, D.H., Naurer, L.H., Sorenson, G.D., Robinson, A.G. and Zimmerman, E.A. (1977). Isolation and characterization of a hormone-producing cell line from human small-cell anaplastic carcinoma of the lung. J. Natl. Cancer Inst. 58: 511–516.
Pettengill, O.S., Sorenson, G.D., Wurster-Hill, D.H., Curphey, T.J., Noll, W.W., Cate, C.C. and Maurer, L.H. (1980). Isolation and growth characteristics of continuous cell lines from small-cell carcinoma of the lung. Cancer 45: 906–918.
Posner, J.B. (1971). Neurological complications of systemic cancer. Med. Clin. North American, 55: 625–646.
Rabson, A.S., Rosen, S.W., Tashjian, A.H., Weintraub, B.D. (1973). Production of human chorionic gonadotropin invitro by a cell line derived from carcinoma of the lung. J. Natl. Cancer Inst. 50: 669–674.
Sorenson, G.D., Pettengill, O.S., Brinck-Johnsen, T., Cate, C.C. and Maurer, L.H. (1981). Hormone production by cultures of small-cell carcinoma of the lung. Cancer 47: 1289–1296.
Steinacker, A. (1977). Calcium dependent presynaptic action of Sub-P at the frog neuromuscular junction. Nature, 267: 268–270.
Stolinsky, D.C. (1980). Paraneoplastic syndromes. West J. Med. 132: 189–208.
Wilkinson, M., Croft, P.B. and Urich, H. (1967). The remote effects of cancer on the nervous system. Proc. R. Soc. Hed. 60: 683–692.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Martinus Nijhoff Publishing, Boston
About this chapter
Cite this chapter
Abdul-Ghani, M.A., Silberberg, S.D., Johnston, M.F., Kravitz, E.A., Meiri, H., Rahamimoff, R. (1986). The Role of Peptides Released by Small Cell Carcinoma of the Lung on Neuromuscular Transmission: Calcitonin. In: Rahamimoff, R., Katz, B. (eds) Calcium, Neuronal Function and Transmitter Release. Topics in the Neurosciences, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2307-5_42
Download citation
DOI: https://doi.org/10.1007/978-1-4613-2307-5_42
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9420-7
Online ISBN: 978-1-4613-2307-5
eBook Packages: Springer Book Archive