Regulation of Voltage-Sensitive Calcium Channels in Brain by Micromolar Affinity Benzodiazepine Receptors

  • R. J. DeLorenzo
  • W. C. Taft
  • W. T. Andrews
Part of the Topics in the Neurosciences book series (TNSC, volume 1)


Ca2+ is an important mediator of molecular events in the functioning nerve terminal (1, 2). An increase in cytoplasmic Ca2+ has been shown to regulate a variety of neuronal cell functions, including neurotransmitter release, stimulation of protein phosphorylation, and synaptic morphological changes (3). It is well-established that these events are directly dependent on the entry of extracellular Ca2+ into the presynaptic nerve terminal through specific voltage-gated Ca2+ channels (4,6). The central role of Ca2+ channels in stimulus-secretion coupling mechanisms has led to the extensive investigation of Ca2+ channel function in a wide variety of intact and broken cell preparations (7). Despite extensive electrophysiological characterization of Ca2+ channels in brain, the molecular nature and pharmacological characteristics of this major neuronal Ca2+ channel remain largely unclear.


Neurotransmitter Release Presynaptic Nerve Terminal Neuronal Cell Function Intact Synaptosome Break Cell Preparation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Martinus Nijhoff Publishing, Boston 1986

Authors and Affiliations

  • R. J. DeLorenzo
  • W. C. Taft
  • W. T. Andrews

There are no affiliations available

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