A Possible Involvement of the Na-Ca Exchanger in Regulation of Transmitter Release at the Frog Neuromuscular Junction

  • Halina Meiri
  • Julian Zelingher
  • Rami Rahamimoff
Part of the Topics in the Neurosciences book series (TNSC, volume 1)

Abstract

While the Important role of calcium ions in transmitter release has been well recognized (del Castillo & Stark, 1952; del Castillo & Katz, 1954; Jenkinson, 1957; Dodge & Rahamimoff, 1967; Katz & Miledi, 1969; Miledi, 1973), the involvement of sodium ions in regulation of the release process — although evident since 1952 (Fatt & Katz, 1952) — is still not completely understood. Sodium ions, although cannot replace calcium in the release process itself, can modulate the number of released transmitter quanta by controlling the metabolism of calcium in the nerve terminal (Kelly, 1965; Birks & Cohen, 1968; Colomo & Rahamimoff, 1968; Lev Tov & Rahamimoff, 1980). Both the influx of calcium ions into the depolarized neuronal axon and their extrusion from the axoplasm, are affected by extracellular sodium.

Keywords

Permeability Sucrose Magnesium Lithium EDTA 

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Copyright information

© Martinus Nijhoff Publishing, Boston 1986

Authors and Affiliations

  • Halina Meiri
    • 1
  • Julian Zelingher
    • 1
  • Rami Rahamimoff
    • 1
  1. 1.Department of PhysiologyHebrew University-Hadassah Medical SchoolJerusalemIsrael

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